Purpose: To evaluate retinal function in patients on hydroxychloroquine using multifocal electroretinography.
Methods: A retrospective chart review was performed for 23 patients (46 eyes) on hydroxychloroquine therapy and referred for multifocal electroretinogram (mfERG) testing. Duration of treatment, daily hydroxychloroquine dose, visual acuity, fundus examination, color vision testing, Amsler grid testing, visual field examination, and fluorescein angiography results were obtained when available. Multifocal electroretinogram response amplitudes were calculated for the central and paracentral regions and compared with previously published normal values. The central and paracentral regions of the mfERG color difference plot, which assigns colors to localized areas of the mfERG based on deviation from normal, were assessed using a novel Color Difference Plot Scoring System which relies on the color pattern observed within each region.
Results: Ninety-two regions were assessed for response amplitudes, 31 of which showed a depressed response amplitude. Of the 17 eyes which had at least one region with a depressed response amplitude, clinical examination findings were relatively benign. Color difference plot scoring showed strong agreement with response amplitude, with a Color Difference Plot Scoring System score of 2 or 3 showing 93.55% sensitivity and 60% specificity for a depressed response amplitude. Interrater reliability of the scoring system as measured by Kendall's W coefficient of concordance was 0.6484 (P < 0.00001).
Conclusion: The mfERG appears to be able to detect decreased retinal function in hydroxychloroquine patients with normal clinical examinations, and may be useful in identifying patients that require close monitoring for the development of clinically relevant toxicity. The Color Difference Plot Scoring System may be used as a tool to aid in the interpretation of results of the mfERG in the clinic setting.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/IAE.0b013e318181445b | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Supramolecular Gelation Based on Native Amino Acid Tyrosine and Its Charge-Transfer Complex Formation.
Langmuir
January 2025
Department of Chemistry, University of North Bengal, Raja Rammohanpur, Siliguri 734013, West Bengal, India.
Self-assembly of amino acids and short-peptide derivatives attracted significant curiosity worldwide due to their unique self-assembly process and wide variety of applications. Amino acid is considered one of the important synthons in supramolecular chemistry. Self-assembly processes and applications of unfunctionalized native amino acids have been less reported in the literature.
View Article and Find Full Text PDFFrom a bee's eye: Effects of UV bullseye size on reproductive success in a dioecious vine (Cucurbitaceae).
Plant Divers
November 2024
The Germplasm Bank of Wild Species, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Descriptions of floral traits based on the visual capabilities of pollinators would advance our understanding of flower evolution and plant-pollinator relationships. One such trait is the contrasting UV bullseye color pattern, which is invisible to human eyes but can be perceived by bee pollinators. However, it remains largely unknown how UV bullseye size affects male and female reproductive fitness.
View Article and Find Full Text PDFRadiation dosimetry performance appraisal of the optimal concentration of nitro blue tetrazolium dye in PVA composite film at low X-ray doses.
Heliyon
January 2025
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.
Purpose: Due to the extensive use of radiation in various fields, such as food safety, sterilizing surgical materials, and medical diagnostics, it is essential to minimize radiation exposure for both patients and healthcare professionals, even at low doses. To meet this requirement, a composite film has been developed using polyvinyl alcohol (PVA) polymer and nitro blue tetrazolium (NBT) dye to measure low radiation doses effectively.
Methods: Various concentrations of NBT dye (ranging from 0.
Impact of Different Time Intervals on the Color Stability of Glass Ionomer Cement and Composite Materials Bonded to Silver Diamine Fluoride: An In Vitro Study.
Cureus
December 2024
Pedodontics and Preventive Dentistry, SRM Kattankulathur Dental College, Chennai, IND.
Objective This in vitro study evaluated the impact of different time intervals on the color stability of glass ionomer cement (GIC) and composite materials bonded to teeth treated with silver diamine fluoride (SDF). Specifically, the study sought to determine if immediate or delayed application of these restorative materials affects the degree of staining caused by SDF. Materials and methods Twenty-eight extracted primary molars with cavitated lesions were randomly divided into four groups, each comprising seven samples.
View Article and Find Full Text PDFQuantitative analysis of retinal vascular parameters changes in school-age children with refractive error using artificial intelligence.
Front Med (Lausanne)
December 2024
The Department of Ophthalmology of the First Affiliated Hospital, Gannan Medical University, Ganzhou, Jiangxi, China.
Aim: To quantitatively analyze the relationship between spherical equivalent refraction (SER) and retinal vascular changes in school-age children with refractive error by applying fundus photography combined with artificial intelligence (AI) technology and explore the structural changes in retinal vasculature in these children.
Methods: We conducted a retrospective case-control study, collecting data on 113 cases involving 226 eyes of schoolchildren aged 6-12 years who attended outpatient clinics in our hospital between October 2021 and May 2022. Based on the refractive spherical equivalent refraction, we categorized the participants into four groups: 66 eyes in the low myopia group, 60 eyes in the intermediate myopia group, 50 eyes in the high myopia group, and 50 eyes in the control group.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!