A 93-year-old woman was referred to our clinic for abnormal genital bleeding. It was found that she had endometrial hyperplasia and breast cancer. Her uterus was as large as that of a normal adult menstruating woman. She indicated that she had been applying cosmetic cream containing a low concentration of ethynylestradiol to her face and body three times a day for 75 years. It is possible that this long-term use of the ethynylestradiol-containing cream is related to the development of breast cancer and endometrial hyperplasia.
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| http://dx.doi.org/10.1097/gme.0b013e318172847d | DOI Listing |
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