We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron.
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| http://dx.doi.org/10.1128/JB.01256-08 | DOI Listing |
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The SaeRS two-component system regulates virulence gene expression in group B during invasive infection.
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