Relation of Trp64Arg polymorphism of beta3-adrenoreceptor gene with cardiovascular risk factors in presurgical morbidly obese patients.

Background: Genetic background of presurgical morbidly obese patients may have an influence on follow-up and outcome. A genetic variant is the Trp64Arg missense mutation in the beta3-adrenoreceptor (beta3-AR) gene.

Methods: We investigated the influence of the Trp64Arg polymorphism in the beta3-AR gene on adipocytokines and cardiovascular risk factors in presurgical morbidly obese patients. A population of 56 presurgical morbidly obese patients was analyzed. Indirect calorimetry, tetrapolar bioimpedance, blood pressure, serial assessment of nutritional intake with a 3-day written food record, and biochemical parameters were measured. Genotype of beta3-AR gene polymorphism (Trp64Arg) was studied.

Results: Mean age was 50.2+/-4.2 years and mean BMI was 46.8+/-4.7 with 11 males (19.6%) and 45 females (80.4%). There were 45 patients (9 males/36 females) (80.4%) who had the genotype Trp64/Trp64 (wild-type group) with an average age of 53.2+/-14 years, and there were 11 patients (2 males/9 females) Trp64/Arg64 (19.6%) (mutant group) with an average age of 47.7+/-15.6 years. In the mutant group, body mass index (BMI), weight, fat mass, waist circumference, total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, fibrinogen, and C-reactive protein (CRP) were higher than wild-type group. Adipocytokine levels were similar in both groups.

Conclusions: In the mutant group of beta3-AR gene (Trp64/Arg64), presurgical morbidly obese patients have a poorer inflammatory profile, lipid profile and fat distribution than wild-type group. Perhaps a future presurgical evaluation of morbidly obese patients would be necessary for genetic profiling.