AI Article Synopsis
- Cross-sectional studies show some male athletes have lower total and bioavailable testosterone related to body weight loss, higher cortisol, or altered LH release.
- In a 6-month study with 15 sedentary men who started endurance training, total testosterone and free androgen index levels significantly decreased, despite reductions in PRL and cortisol.
- The weight loss seen during training did not correlate with changes in testosterone, and LH pulsatile release remained unchanged, indicating the decrease in testosterone isn’t linked to common factors like weight or cortisol levels.
Article Abstract
Cross-sectional studies have suggested that total and bioavailable testosterone levels are reduced in some male athletes. Such changes may be related to loss of body weight, increased serum cortisol, and/or alterations in LH pulsatile release. To determine how endurance training may affect androgen levels, we measured serum total testosterone, sex hormone-binding globulin, free androgen index, LH, FSH, PRL, cortisol, and weight in 15 previously sedentary males. We also examined pulsatile LH release in a subset of 5 subjects. Over 6 months of training, the men increased weekly running mileage to an average of 56 km/week. Total testosterone and free androgen index levels decreased significantly. PRL and cortisol also decreased, while single sample LH and FSH remained unchanged. There was a significant reduction in weight, which did not correlate with changes in serum testosterone levels. LH pulsatile release was not altered by training in the subset of 5 runners. These data confirm previous findings of physiological reduction in serum testosterone and PRL levels and suggest that the testosterone decrease is not related to changes in LH pulsatile release, weight, or increased serum cortisol levels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1210/jcem-72-2-422 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characteristics of Tylvalosin Tartrate Enteric Amorphous Pellets Prepared by Liquid Layering.
Pharm Res
January 2025
Department of Pharmaceutics Science, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Purpose: Tylvalosin Tartrate (TAT), a new-generation macrolide antibiotic, undergoes significant degradation in the stomach and in vivo rapid elimination upon oral administration, resulting in poor bioavailability. This study developed TAT enteric amorphous pellets by liquid layering (TAT/EAP-LL) with pH-sensitive and burst release characteristics, to enhance drug stability in the stomach and concentration enrichment in the duodenum.
Methods: The drug loading layer, isolation layer and enteric layer were formed on the surface of the blank core pellets.
Kisspeptin control of hypothalamus-pituitary-ovarian functions.
Vitam Horm
January 2025
Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar pradesh, India.
The discovery of Kisspeptin (Kiss) has opened a new direction in research on neuroendocrine control of reproduction in vertebrates. Belonging to the RF amide family of peptides, Kiss and its cognate receptor Gpr54 (Kissr) have a long and complex evolutionary history. Multiple forms of Kiss and Kissr are identified in non-mammalian vertebrates, with the exception of birds, and monotreme mammals.
View Article and Find Full Text PDFIdentification of puberty related miRNAs in the hypothalamus of female mice.
Mol Cell Endocrinol
January 2025
Department of Molecular Genetics, Function and Therapy, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus. Electronic address:
Background And Aims: Puberty is a crucial developmental stage marked by the transition from childhood to adulthood, organized by complex hormonal signaling within the neuroendocrine system. The hypothalamus, a central region in this system, regulates pubertal functions through the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-releasing hormone (GnRH) neurons, essential in puberty control, release GnRH in a pulsatile manner, initiating the production of sex hormones.
View Article and Find Full Text PDFRobotic-assisted excision of left para-aortic paraganglioma: a novel approach.
J Surg Case Rep
January 2025
Department of Endocrine Surgery, Royal Victoria Infirmary, Newcastle Upon Tyne NE1 4LP, United Kingdom.
Paragangliomas, a type of extra-adrenal tumour, albeit rare, are dangerous due to their high metastatic potential and risk of hypertensive crisis from massive catecholamine release. It typically presents with sympathetic overdrive symptoms such as diaphoresis, headache, and palpitation, accompanied by substantially high plasma metanephrines level and mass on contrasted computed tomography abdomen and pelvis, whilst some are found incidentally. In this report, we discuss a case of an extra-adrenal lesion located near susceptible major structures with extensive vascularisation, in a patient with near-death experience.
View Article and Find Full Text PDFKisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders.
Andrology
January 2025
Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK.
The hypothalamic-pituitary-gonadal axis is regulated by the gonadotropin-releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and gametogenesis from the gonads. Many reproductive disorders in both males and females are characterized by hypothalamic dysfunction, including functional disorders (such as age-related hypogonadism, obesity-related secondary hypogonadism, hyperprolactinemia, functional hypothalamic amenorrhea and polycystic ovary syndrome), structural pathologies (such as craniopharyngiomas or radiation or surgery-related hypothalamic dysfunction), and pubertal disorders (constitutional delay of growth and puberty and congenital hypogonadotropic hypogonadism).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!