Normal unstimulated lymphocytes cocultured with normal bone marrow will inhibit day-7 colony- forming units in culture. We have shown that this phenomenon has a molecular basis and attempted to characterize it further. Using specific assays and neutralizing monoclonal antibodies we have found that this granulopoietic inhibitory activity (GIA) is not due to alpha- or gamma-interferon, tumor necrosis factor, or acidic or basic isoferritins. Biochemical studies suggest that it is a glycoprotein with a molecular weight greater than 100,000 daltons. It appears to act on cells in S phase, although it may not be S-phase specific. GIA represents a novel inhibitor that merits further investigation.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Exploration of Cytokines and Microbiome Among Males and Females with Diarrhea-Predominant Irritable Bowel Syndrome.
Dig Dis Sci
January 2025
School of Nursing, University of Washington, Seattle, WA, USA.
Background: Whether pathophysiological factors differ between males and females with irritable bowel syndrome-diarrhea (IBS-D) remains to be tested. To better understand potential sex differences, males with IBS-D were compared to naturally cycling females and to females with IBS-D taking hormonal contraception on plasma levels of cytokines and gut microbiome characteristics.
Methods: Males and females with Rome III IBS-D completed questionnaires and kept a daily symptom diary for 28 days.
Burning Tongue and Taste Alteration in Xerostomic Undiagnosed Diabetic Patients with Vitamin D Deficiency.
Diabetes Metab Syndr Obes
November 2024
Department of Oral Medicine, Faculty of Dentistry, Padjadjaran University, Bandung, West Java, Indonesia.
Article Synopsis
- * A 44-year-old woman presented with these symptoms, and after blood tests and other assessments showed normal results, she was treated with several therapies including mouthwash and vitamins.
- * Further investigations revealed she had diabetes and vitamin D deficiency, leading to improved symptoms after targeted treatment, emphasizing the importance of thorough evaluations for similar cases.
Reduced Salivary Gustin and Statherin in Long-COVID Cohort with Impaired Bitter Taste.
J Clin Med
November 2024
Oral Pathology, Medicine and Radiology, Indiana University School of Dentistry, Indianapolis, IN 46202, USA.
Article Synopsis
- Taste dysfunction is a common symptom in individuals with long COVID, with 20-25% experiencing persistent issues, particularly with bitter taste perception.
- The study found that people with long COVID had significantly lower levels of salivary gustin, a protein that affects taste, which correlated with a reduced ability to taste bitterness.
- Sonic hedgehog (SHH) and other specific cell markers were identified in saliva, indicating potential mechanisms behind taste dysfunction in long COVID patients.
Effect of Comparable Carbon Chain Length Short- and Branched-Chain Fatty Acids on Adipokine Secretion from Normoxic and Hypoxic Lipopolysaccharide-Stimulated 3T3-L1 Adipocytes.
Biomedicines
November 2024
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Microbial fermentation of non-digestible carbohydrates and/or protein produces short-chain fatty acids (SCFA), whereas branched-chain fatty acids (BCFA) are produced from protein fermentation. The effects of individual SCFA and BCFA of comparable carbon chain length on adipocyte inflammation have not been investigated. : To compare the effects of SCFA and BCFA on inflammatory mediator secretion in an adipocyte cell culture model designed to recapitulate obesity-associated adipocyte inflammation under normoxic and hypoxic conditions.
View Article and Find Full Text PDFAlterations in salivary profile in individuals with dental caries and/or obesity: A systematic review and meta-analysis.
J Dent
December 2024
Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, China. Electronic address:
Objectives: To investigate current evidence on the association of salivary profile with dental caries and obesity.
Data/sources: A comprehensive search was conducted on PubMed, Web of Science, Embase, ProQuest Medical Database, ProQuest Sci-Tech Premium, and Cochrane Library up to June 2024. Observational studies comparing salivary profiles in individuals with dental caries and/or obesity were included.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!