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Position in proton Bragg curve influences DNA damage complexity and survival in head and neck cancer cells.
Clin Transl Radiat Oncol
March 2025
Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
Background And Purpose: Understanding the cellular and molecular effect of proton radiation, particularly the increased DNA damage complexity at the distal end of the Bragg curve, is current topic of investigation. This work aims to study clonogenic survival and DNA damage foci kinetics of a head and neck squamous cell carcinoma cell line at various positions along a double passively scattered Bragg curve. Complementary studies are conducted to gain insights into the link between cell survival variations, experimentally yielded foci and the number and complexity of double strand breaks (DSBs).
View Article and Find Full Text PDFImpact of ozone concentration on the treatment effectiveness of diabetic foot syndrome: a pilot single-centre study.
Postepy Dermatol Alergol
December 2024
Department of Internal Medicine, Angiology and Physical Medicine in Bytom, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Introduction: Diabetic foot syndrome (DFS) a severe complication of diabetes which can result in ulcers, infections, or tissue damage in the feet.
Aim: To compare the treatment effectiveness in patients with DFS using local O therapy depending on the O concentration.
Material And Methods: The study included 50 patients, 24 male and 26 female ones, in the age range between 39 and 84 years, with DFS.
Facile Access to Highly Efficient 3D Printing Using Robust Self-Healing CDs/Polymer Hybrids.
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Jiangsu Key Laboratory of Fine Chemicals and Functional Polymer Materials, Nanjing Tech University, No. 5 Xin Mofan Road, Nanjing 210009, P. R. China.
3D printing efficiency, as a key indicator of additive manufacturing technology, directly affects its competitiveness in rapid prototyping, small batch production, and even large-scale industrial applications. Compared with traditional manufacturing methods, the high efficiency of 3D printing is often considered a bottleneck, hindering its application across various fields. Herein, a versatile and efficient strategy is proposed, namely, the dimensional reduction printing (DRP) process, to break the obstacle of high efficiency of 3D printing.
View Article and Find Full Text PDFOptimal Neutron Spectrum Database for In-reactor Pu Production.
Adv Sci (Weinh)
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Science and Technology on Reactor System Design Technology Laboratory, Nuclear Power Institute of China, Chengdu, 610200, China.
Plutonium-238 (Pu) is a scarce heat-source radioisotope used in nuclear batteries, which is produced by in-reactor irradiation of Americium-241 (Am) or Neptunium-237 (Np). Optimizing the neutron spectrum can improve the production efficiency of Pu, but currently, it is still a lack of knowledge about the optimal neutron spectrum for Pu production. Genetic algorithms and burnup algorithms are combined to identify optimal neutron spectra for Pu production under various irradiation times and flux levels, and build an optimal neutron spectrum database, which answers the questions "What is the optimal neutron spectrum for Pu production?" and "What is the maximum efficiency for Pu production" once and for all.
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