Surgical haemostatic agents have been increasingly applied for the control of bleeding, and have excellent potential in laparoscopy. Several factors are important when evaluating the use of sealants. We present a brief overview of the history, composition and mechanism of action of sealants, together with a report on experimental studies and clinical experience with haemostatic sealants. We searched for reports on haemostatic agents and their use in renal parenchymal haemostasis; 15 animal models studies and 11 papers on clinical experience were included. The development of haemostatic agents and instruments is allowing the wider diffusion of challenging procedures. Several experimental animal studies have shown the efficacy and safety of sealants for haemostasis during nephron-sparing surgery. Clinical studies confirm the effectiveness of synthetic or fibrin glue, in particular during laparoscopic surgery. Sealants are effective and safe topical agents to control bleeding during nephron-sparing surgery. They should not be viewed as an alternative, but as complementary agents to be used to improve surgical outcomes. Further prospective studies are necessary to validate their role in relation to other haemostatic support techniques.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1464-410X.2008.08035.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nephron-sparing Surgery for Pediatric Renal Tumors After Centralization of Pediatric Oncology Care in the Netherlands: Improved Outcomes With 3D Modeling.
J Pediatr Surg
December 2024
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Background And Aim: In this retrospective single center cohort study, we report the surgical outcomes of nephron-sparing surgery (NSS) for Wilms' tumor (WT) patients since centralization of pediatric oncology care in the Netherlands, and implementation of technological advancements. Therewith we describe the influence of experience and innovations for this type of surgery.
Methods: We retrospectively assessed all NSS procedures from January 1st 2015 until January 1st 2024 for patients who underwent surgery for a renal tumor at the Princess Máxima Center for Pediatric Oncology.
A novel nephrometry scoring system outperforms RENAL score, PADUA score, and SPARE score for feasibility prediction of nephron-sparing surgery in children with bilateral Wilms tumor.
Quant Imaging Med Surg
December 2024
Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Article Synopsis
- The study aimed to assess the predictive accuracy of a new nephrometry model (RSR) for nephron-sparing surgery in pediatric patients with Wilms tumor, comparing it to existing models.
- Data from 58 pediatric patients were analyzed, calculating nephrometry scores such as RENAL, PADUA, and SPARE, and the RSR model showed superior predictive performance with an area under the curve (AUC) of 0.982.
- The RSR model not only outperformed the other nephrometry scores significantly but also demonstrated good inter-rater reliability, leading to the development of a user-friendly web-based calculator for its application.
Wilms' Tumor - An Audit.
J Indian Assoc Pediatr Surg
November 2024
Department of Pathology, Lady Hardinge Medical College and Associated Kalawati Children's Hospital, New Delhi, India.
Background And Aims: Outcome analysis of patients with Wilms' tumors (WT) is presented.
Materials And Methods: A retrospective analysis of 23 children having WT managed by a single surgeon over 3 years (2021-2024) using the International Society of Paediatric Oncology Umbrella protocol was done.
Results: The median age at presentation was 36 months; 32 months and 24 months for the unilateral WT (uWT) ( = 19) and bilateral WT (bWT) ( = 4), respectively.
Introduction: This study aims to evaluate the impact of preoperative ureteral stenting on postoperative outcomes, especially the incidence of urinoma, in patients with complex renal tumors undergoing nephron-sparing surgery.
Methods: A retrospective analysis of 35 patients who received preoperative ureteral stenting prior to nephron-sparing surgery for complex tumors at the University Hospital of Würzburg between 2002 and 2021. A control group of 115 patients was established through 1:3 propensity score matching based on age, gender, T-stage, and RENAL score.
Tracing the evolving dynamics and research hotspots in the kidney neoplasm and nephron sparing surgery field from the past to the new era.
Cancer Med
June 2024
Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- * An analysis of 7,564 publications related to kidney neoplasms revealed a significant increase in research output, with U.S. institutions like the Cleveland Clinic leading in contributions.
- * Key research areas identified include optimal management options for patients, the comparative effectiveness of surgical techniques, and the need for the development of new technologies in surgical practices.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!