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Progestins as a Contributing Factor to Hepatocellular Adenoma: A Case Series and Literature Review.
J Pediatr Adolesc Gynecol
April 2024
Department of Paediatric and Adolescent Gynaecology, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
Study Objective: To explore the role of progestins as potential contributing factors for the development of hepatocellular adenoma (HA) METHODS: We describe 3 cases of adolescents and young adults who developed HA while on norethindrone (NET), as well as their management. In addition, we provide a comprehensive literature review on the association between progestins and HA.
Results: Since 1983, 16 cases of HA in patients on progestins have been reported.
Detection of doping control sample substitutions via single nucleotide polymorphism-based ID typing.
Drug Test Anal
December 2023
Center for Preventive Doping Research, Institute of Biochemistry, German Sport University Cologne, Cologne, Germany.
The authenticity of a doping control sample is a key element of sports drug testing programmes. Doping control sample manipulation by providing another individual's urine or blood (instead of the tested athlete's sample) has been observed in the past and is an unequivocal violation of the World Anti-Doping Agency anti-doping rules. To determine attempts of manipulations by sample swapping, the utility of a single nucleotide polymorphism (SNP)-based sample authentication with a multi-target SNP panel was assessed.
View Article and Find Full Text PDFThe AF-2 cofactor binding region is key for the selective SUMOylation of estrogen receptor alpha by antiestrogens.
J Biol Chem
January 2023
Institut de Recherche en Immunologie et Cancérologie (IRIC), Université de Montréal, Montréal, Québec, Canada; Département de Biochimie et Biologie Moléculaire, Université de Montréal, Montréal, Québec, Canada. Electronic address:
Antiestrogens (AEs) are used to treat all stages of estrogen receptor (ER)-positive breast cancer. Selective estrogen receptor modulators such as tamoxifen have tissue-specific partial agonist activity, while selective estrogen receptor downregulators such as fulvestrant (ICI182,780) display a more complete antiestrogenic profile. We have previously observed that fulvestrant-induced ERα SUMOylation contributes to transcriptional suppression, but whether this effect is seen with other AEs and is specific to ERα is unclear.
View Article and Find Full Text PDFMitochondrial [2Fe-2S] ferredoxins: new functions for old dogs.
FEBS Lett
January 2023
Institut für Zytobiologie, Philipps-Universität Marburg, Germany.
Ferredoxins (FDXs) comprise a large family of iron-sulfur proteins that shuttle electrons from NADPH and FDX reductases into diverse biological processes. This review focuses on the structure, function and specificity of mitochondrial [2Fe-2S] FDXs that are related to bacterial FDXs due to their endosymbiotic inheritance. Their classical function in cytochrome P450-dependent steroid transformations was identified around 1960, and is exemplified by mammalian FDX1 (aka adrenodoxin).
View Article and Find Full Text PDFFunctional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2.
Nat Chem Biol
February 2023
Institute for Cytobiology, Philipps University of Marburg, Marburg, Germany.
Ferredoxins comprise a large family of iron-sulfur (Fe-S) proteins that shuttle electrons in diverse biological processes. Human mitochondria contain two isoforms of [2Fe-2S] ferredoxins, FDX1 (aka adrenodoxin) and FDX2, with known functions in cytochrome P450-dependent steroid transformations and Fe-S protein biogenesis. Here, we show that only FDX2, but not FDX1, is involved in Fe-S protein maturation.
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