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Current and emerging treatment modalities for fibrodysplasia ossificans progressiva.
Expert Opin Pharmacother
November 2024
Department of Medical Pharmacology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
Article Synopsis
- Heterotopic ossification (HO) is a condition characterized by the abnormal formation of bone in soft tissues and can be caused by trauma or genetic factors, with Fibrodysplasia ossificans progressiva (FOP) being a rare hereditary type that severely impacts individuals' health.
- The FDA recently approved palovarotene, the first drug specifically for treating HO in FOP patients, marking a significant development in therapeutic options for this condition.
- While the introduction of palovarotene could change treatment approaches, there is still a concern due to the absence of long-term safety and efficacy data for this new medication.
Comparison of PET/CT versus CT only in the assessment of new heterotopic ossification bone lesions in patients with fibrodysplasia ossificans progressiva.
Bone
January 2025
Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Article Synopsis
- Fibrodysplasia ossificans progressiva (FOP) is a rare condition where bones form in soft tissue, referred to as heterotopic ossification (HO), and this study examined imaging methods to identify and measure new HO lesions.
- The research analyzed data from a phase 2 clinical trial comparing the effectiveness of garetosmab (a therapy) with a placebo in adults with FOP, utilizing both PET/CT and CT scans to detect lesions over 28 weeks.
- Results showed that both PET/CT and CT-only methods detected a similar number and volume of new lesions, indicating that CT-only imaging is an effective alternative for monitoring HO changes in FOP patients.
When the Going Gets Tough: A Review of Total Hip Arthroplasty in Patients with Ipsilateral Above- and Below-Knee Amputation.
Medicina (Kaunas)
September 2024
Orthopedic and Traumatology Clinic, IRCCS Rizzoli Orthopedic Institute, Via G.C. Pupilli 1, 40136 Bologna, Italy.
Article Synopsis
- Life expectancy and overall function of amputated patients have improved, leading to a higher incidence of hip issues requiring total hip arthroplasty (THA), but not all surgeons are adequately trained for these cases.
- This review analyzes 17 manuscripts, documenting 39 cases of THA in amputees, highlighting differences between above-knee amputations (AKA) and below-knee amputations (BKA) and emphasizing the need for careful planning and rehabilitation considerations before surgery.
- Patients with BKA often have higher functional demands post-surgery, requiring precise component positioning and intensive physiotherapy, while AKA patients may present unique challenges due to the lack of a knee joint and varying levels of mobility.
Deciphering the evolutionary development of the "Chinese lantern" within Solanaceae.
Planta
September 2024
State Key Laboratory of Plant Diversity and Specialty Crops/State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Nanxincun 20, Xiangshan, Beijing, 100093, China.
The key genetic variation underlying the evo-devo of ICS in Solanaceae may be further pinpointed using an integrated strategy of forward and reverse genetics studies under the framework of phylogeny. The calyx of Physalis remains persistent throughout fruit development. Post-flowering, the fruiting calyx is inflated rapidly to encapsulate the berry, giving rise to a "Chinese lantern" structure called inflated calyx syndrome (ICS).
View Article and Find Full Text PDFThe dual role of CCND1 in heterotopic ossification: A Non-canonical Pathway for Celecoxib treatment.
Heliyon
August 2024
Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Objective: To explore the effective targets of Celecoxib in the treatment of heterotopic ossification using network pharmacology methods.
Methods: Potential molecules related to heterotopic ossification were obtained by retrieving the GEO and CTD databases and intersecting them. Potential binding targets of Celecoxib were acquired from the STITCH database.
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