Treatment-related myelodysplastic syndrome after temozolomide use in a child: first report.

J Pediatr Hematol Oncol

Département de Cancérologie de l'Enfant et de l'Adolescent, Institut Gustave Roussy, 39, rue Camille Desmoulins, Villejuif cedex 94805, France.

Published: November 2008

Temozolomide is an effective alkylating agent that is increasingly used for the treatment of pediatric brain tumors. Secondary, or treatment-related, myelodysplasia is a life-threatening complication of alkylating chemotherapy and has been reported in children with brain tumors after treatments other than temozolomide. We describe for the first time a case of temozolomide-related myelodysplasia in a child.

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Source
http://dx.doi.org/10.1097/MPH.0b013e318182e74fDOI Listing

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