Background And Purpose: Currently, the effect of the volume of cement used during sacroplasty on the restoration of pelvic strength and stiffness is unknown. The purpose of this study was to measure that effect in a sacral insufficiency fracture model.
Materials And Methods: Twenty-five osteoporotic cadaveric pelves were potted, and sacral fractures were produced. Specimens were divided into 4 groups: group 0 + 0 (control), no sacroplasty; group 3 + 0, sacroplasty (posterior approach), 3 mL of a bone cement injected bilaterally into the fracture site at S1; group 3 + 3, sacroplasty (posterior approach), 3 mL of the same cement injected bilaterally into the fracture site at S1 and S2; and group 6 + 3, sacroplasty (posterior approach), 6 mL of the same cement injected bilaterally at S1 and 3 mL injected bilaterally at S2. Cement position and extravasation were documented with CT. Specimens were tested to failure to assess the strength and stiffness after sacroplasty.
Results: There were no significant differences in strength or stiffness restoration between control and treatment groups.
Conclusions: Sacroplasty does not restore the strength or stiffness of the sacrum in a cadaveric model regardless of the volume or location of cement.
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http://dx.doi.org/10.3174/ajnr.A1358 | DOI Listing |
Geroscience
January 2025
Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ageing is the primary driver of age-associated chronic diseases and conditions. Asian populations have traditionally been underrepresented in studies understanding age-related diseases. Thus, the Ageing BIOmarker Study in Singaporeans (ABIOS) aims to characterise biomarkers of ageing in Singaporeans, exploring associations between molecular, physiological, and digital biomarkers of ageing.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Civil Engineering, University of Guilan, Rasht, Iran.
Glassphalt suffers from performance defects, especially against moisture damage and fatigue cracking. In this research, the performance of glassphalt modified with CF has been evaluated against moisture damage, fatigue cracking and rutting. Based on this, Modified Lottman, Wilhelmy Plate (WP), Indirect Tensile Stiffness Modulus (ITSM), Indirect Tensile Fatigue (ITF), and Repeated Load Axial (RLA) tests have been performed on glassphalt modified with CF.
View Article and Find Full Text PDFJ Mech Behav Biomed Mater
January 2025
Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA; Center for Multiscale and Translational Mechanobiology, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Despite the broad agreement that bone stiffness is heavily dependent on the underlying bone density, there is no consensus on a unified relationship that applies to both cancellous and cortical compartments. Bone from the two compartments is generally assessed separately, and few mechanical test data are available for samples from the transitional regions between them. In this study, we present a data-driven framework integrating experimental testing and numerical modeling of the human lumbar vertebra through an energy balance criterion, to develop a unified density-modulus relationship across the entire vertebral body, without the necessity of differentiation between trabecular and cortical regions.
View Article and Find Full Text PDFRheumatol Int
January 2025
Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Health Service Research and Innovation Unit, Oslo, Norway.
Objective: This protocol paper describes the rationale and design of a randomised controlled trial (RCT) that aims to evaluate the (cost-)effectiveness of a 12 week e-self-management intervention (Happy Hands app) in people with hand osteoarthritis (HOA).
Methods: In this multicentre RCT, 376 people with HOA will be recruited from all four health regions in Norway. Consenting participants will be randomly allocated to either a control group receiving usual care or an intervention group receiving the Happy Hands app in addition to usual care.
Science
January 2025
Department of Chemistry, Northwestern University, Evanston, IL, USA.
Mechanical bonds arise between molecules that contain interlocked subunits, such as one macrocycle threaded through another. Within polymers, these linkages will confer distinctive mechanical properties and other emergent behaviors, but polymerizations that form mechanical bonds efficiently and use simple monomeric building blocks are rare. In this work, we introduce a solid-state polymerization in which one monomer infiltrates crystals of another to form a macrocycle and mechanical bond at each repeat unit of a two-dimensional (2D) polymer.
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