AI Article Synopsis
- This study investigates how growth and fate determination of tissues are regulated in the Drosophila wing primordium during larval development.
- The opposing actions of the Wingless and Vein signaling molecules dictate whether cells develop into wing or body wall tissues.
- Notch signaling plays a significant role in linking tissue growth to fate specification, showing that the size of the tissue influences the activity of the signaling molecules involved.
Article Abstract
During the development of a given organ, tissue growth and fate specification are simultaneously controlled by the activity of a discrete number of signalling molecules. Here, we report that these two processes are extraordinarily coordinated in the Drosophila wing primordium, which extensively proliferates during larval development to give rise to the dorsal thoracic body wall and the adult wing. The developmental decision between wing and body wall is defined by the opposing activities of two secreted signalling molecules, Wingless and the EGF receptor ligand Vein. Notch signalling is involved in the determination of a variety of cell fates, including growth and cell survival. We present evidence that growth of the wing primordium mediated by the activity of Notch is required for wing fate specification. Our data indicate that tissue size modulates the activity range of the signalling molecules Wingless and Vein. These results highlight a crucial role of Notch in linking proliferation and fate specification in the developing wing primordium.
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| http://dx.doi.org/10.1242/dev.027789 | DOI Listing |
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