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The hidden island of addiction: the insula. | LitMetric

The hidden island of addiction: the insula.

Trends Neurosci

Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 1032, USA.

Published: January 2009

Most prior research on the neurobiology of addiction has focused on the role of subcortical systems, such as the amygdala, the ventral striatum and mesolimbic dopamine system, in promoting the motivation to seek drugs. Recent evidence indicates that a largely overlooked structure, the insula, plays a crucial part in conscious urges to take drugs. The insula has been highlighted as a region that integrates interoceptive (i.e. bodily) states into conscious feelings and into decision-making processes that involve uncertain risk and reward. Here, we propose a model in which the processing of the interoceptive effects of drug use by the insula contributes to conscious drug urges and to decision-making processes that precipitate relapse.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698860PMC
http://dx.doi.org/10.1016/j.tins.2008.09.009DOI Listing

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