We established a technique for constructing PEGylated gold nanoparticles (GNP) that have small compounds with almost complete functionalities on their surfaces using a newly synthesized hetero-telechelic poly(ethylene glycol) (PEG), and their association/dissociation behavior on an antibody-immobilized surface was evaluated using a surface plasmon resonance (SPR) sensor.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/b811818c | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
PEGylated iron oxide-gold core-shell nanoparticles for tumor-targeted delivery of Rapamycin.
3 Biotech
January 2025
Department of Biotechnology, University of Calicut, Kerala Malappuram, 673635 India.
Rapamycin analogs are approved by the FDA for breast and renal cancer treatment. Hence, the possibility of nanoparticle-mediated delivery of Rapamycin could be examined. In the present study, PEGylated Gold-core shell iron oxide nanoparticles were used for the targeted delivery of Rapamycin, and R-Au-IONPs were formulated.
View Article and Find Full Text PDFAdvances in Dendritic Systems and Dendronized Nanoparticles: Paradigm Shifts in Cancer Targeted Therapy and Diagnostics.
Mol Pharm
January 2025
School of Pharmacy and Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Deemed to be University, Shirpur, Dhule, Maharashtra 425405, India.
Cancer has emerged as a global health crisis, claiming millions of lives annually. Dendrimers and dendronized nanoparticles, a novel class of nanoscale molecules with highly branched three-dimensional macromolecular structures, have gained significant attention in cancer treatment and diagnosis due to their unique properties. These dendritic macromolecules offer a precisely controlled branching architecture, enabling functionalization with specific targeting molecules to enhance the selective delivery of therapeutic agents to tumor cells while minimizing systemic toxicity.
View Article and Find Full Text PDFBlack Phosphorus Nanosheets-Loaded Single-Atom Gold Nanoenzymes for Enhanced Photodynamic Therapy of Hepatocellular Carcinoma.
Int J Nanomedicine
December 2024
Clinical Laboratory of Chun'an First People's Hospital, Zhejiang Provincial People's Hospital Chun'an Branch, Hangzhou, Zhejiang, People's Republic of China.
Article Synopsis
- Conventional treatments for hepatocellular carcinoma (HCC) are often ineffective, prompting interest in photodynamic therapy (PDT) as a targeted alternative.
- Researchers created black phosphorus nanosheets loaded with single-atom gold nanoenzymes to improve PDT effectiveness, enhancing stability and targeting with PEG and folate modifications.
- The developed nanoplatform successfully targets HCC tumors, generates significant reactive oxygen species, and demonstrates improved biocompatibility and catalytic activity, making it a promising option for HCC treatment.
A comprehensive review on alpha-lipoic acid delivery by nanoparticles.
Bioimpacts
February 2024
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Alpha-lipoic acid (ALA) has garnered significant attention for its potential therapeutic benefits across a wide spectrum of health conditions. Despite its remarkable antioxidant properties, ALA is hindered by challenges such as low bioavailability, short half-life, and unpleasant odor. To overcome these limitations and enhance ALA's therapeutic efficacy, various nanoparticulate drug delivery systems have been explored.
View Article and Find Full Text PDFEngineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement.
Adv Mater
December 2024
Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Chemoradiation therapy is on the forefront of pancreatic cancer care, and there is a continued effort to improve its safety and efficacy. Liposomes are widely used to improve chemotherapy safety, and may accurately deliver high-Z element- radiocatalytic nanomaterials to cancer tissues. In this study, the interaction between X-rays and long-circulating nanoliposome formulations loaded with gold nanoclusters is explored in the context of oxaliplatin chemotherapy for desmoplastic pancreatic cancer.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!