Titanium-mediated cross-coupling of allenic alcohols with alkynes has been investigated. Divergent reaction pathways were discovered that provide either stereodefined 1,4-dienes or substituted cross-conjugated trienes. In short, allene substitution plays a critical role in the determination of reaction pathway.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577592 | PMC |
| http://dx.doi.org/10.1016/j.tet.2008.02.015 | DOI Listing |
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