A software strategy to provide intuitive navigation for MRI-guided robotic transperineal prostate therapy is presented. In the system, the robot control unit, the MRI scanner, and open-source navigation software are connected to one another via Ethernet to exchange commands, coordinates, and images. Six states of the system called "workphases" are defined based on the clinical scenario to synchronize behaviors of all components. The wizard-style user interface allows easy following of the clinical workflow. On top of this framework, the software provides features for intuitive needle guidance: interactive target planning; 3D image visualization with current needle position; treatment monitoring through real-time MRI. These features are supported by calibration of robot and image coordinates by the fiducial-based registration. The performance test shows that the registration error of the system was 2.6 mm in the prostate area, and it displayed real-time 2D image 1.7 s after the completion of image acquisition.
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Sci Rep
December 2024
School of Artificial Intelligence and Computer Science, Jiangnan University, Wuxi, 214122, China.
The unknown boundary issue, between superior computational capability of deep neural networks (DNNs) and human cognitive ability, has becoming crucial and foundational theoretical problem in AI evolution. Undoubtedly, DNN-empowered AI capability is increasingly surpassing human intelligence in handling general intelligent tasks. However, the absence of DNN's interpretability and recurrent erratic behavior remain incontrovertible facts.
View Article and Find Full Text PDFBiochem Mol Biol Educ
December 2024
Dirección Académica, Universidad Nacional de Colombia Sede de La Paz, La Paz, Colombia.
The COVID-19 pandemic affected a large range of in-person education activities in Colombia. This created great limitations in academic performance for students with reduced access to communication technologies and deepened the educational gaps in the country. This was particularly true for sciences such as biochemistry.
View Article and Find Full Text PDFLancet Reg Health Southeast Asia
January 2025
ICMR - National Institute for Research in Environmental Health, Bhopal, Madhya Pradesh, India.
Background: India, with the largest population and second-highest type 2 diabetes mellitus (T2DM) prevalence, presents a unique genetic landscape. This study explores the genetic profiling of T2DM, aiming to bridge gaps in existing research and provide insights for further explorations.
Methods: We conducted a systematic review and meta-analysis of literature published up to September 2024 using databases like PubMed, Web of Science, Scopus, and Google Scholar to identify SNPs associated with T2DM in case-control studies within the Indian population.
BMC Health Serv Res
December 2024
Department of Public Health, School of Allied Medical Sciences, Maragheh University of Medical Sciences, Maragheh, Iran.
Background: Futile care is a set of actions without creating a reasonable chance of benefiting critically ill patients. In the COVID-19 pandemic, there is a need to discuss futile care perception. This may cause unbearable pressure for nurses in terms of resilience and turnover intention.
View Article and Find Full Text PDFBMC Genomics
December 2024
School of Computer Science and Technology, Qingdao University, Ningxia Road, Qingdao, Shandong Province, 266071, China.
Background: Discontinuous transcription allows coronaviruses to efficiently replicate and transmit within host cells, enhancing their adaptability and survival. Assembling viral transcripts is crucial for virology research and the development of antiviral strategies. However, traditional transcript assembly methods primarily designed for variable alternative splicing events in eukaryotes are not suitable for the viral transcript assembly problem.
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