AI Article Synopsis
- Neurohormonal activation plays a significant role in the physiological response to heart failure, impacting various body systems.
- The article discusses the activation mechanisms and effects of multiple neurohormonal systems, including the sympathetic nervous system and renin-angiotensin-aldosterone system, among others.
- It serves as a comprehensive reference for nursing professionals, highlighting important pharmacologic agents for managing heart failure and their underlying physiological principles.
Article Abstract
Neurohormonal activation is a commonly cited array of phenomena in the body's physiologic response to heart failure. Although various neurohormones and pharmacologic agents that moderate their pathophysiologic effects have been reviewed in the nursing literature, both the mechanisms of neurohormonal system activation and cellular and organ system effects have been described only in brief. Accordingly, this article reviews mechanisms of neurohormonal activation and describes cellular and cardiovascular effects of the (1) sympathetic nervous system, (2) renin-angiotensin-aldosterone system, (3) kallikrein-kininogen-kinin system, (4) vasopressinergic system, (5) natriuretic peptide systems, and (6) endothelin in the context of heart failure. This article implicitly details the physiologic basis for numerous current and potential future pharmacologic agents used in the management of heart failure. It is intended that this article be used as a reference for advanced clinical nursing practice, research, and education.
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| http://dx.doi.org/10.1097/01.AACN.0000340718.93742.c4 | DOI Listing |
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