AI Article Synopsis
- Researchers aimed to explore the connection between vitamin D levels and cardiac natriuretic peptides in patients on chronic peritoneal dialysis.
- They found that lower levels of vitamin D were significantly associated with higher levels of B-type natriuretic peptide (BNP), suggesting a potential link between vitamin D deficiency and heart function impairment.
- The study concludes that vitamin D deficiency in patients with chronic renal failure may negatively affect cardiac function, as indicated by increased BNP levels.
Article Abstract
Objective: Experimental evidence suggests that vitamin D deficiency impairs cardiac structure and function. Our objective was to observe relationships between circulating levels of the cardiac natriuretic peptides and vitamin D levels in patients on chronic peritoneal dialysis.
Method: Measurements were made of circulating levels of 25-hydroxyvitamin D [25(OH)D] and plasma B-type natriuretic peptide (BNP) levels in patients receiving chronic peritoneal dialysis.
Results: Both BNP and the 1-76 amino-terminal fragment of pro-BNP correlated inversely with 25(OH)D levels (rs = -0.60, p = 0.007, and rs = -0.64, p = 0.003, respectively) in patients on peritoneal dialysis.
Conclusions: Vitamin D deficiency in chronic renal failure may impair cardiac function, as manifested by elevated levels of B-type cardiac natriuretic peptides.
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