Enzyme-based hybrid hydrogels were prepared by covalently incorporating an adenylate kinase mutant, possessing two thiol groups, into HPMA copolymer- or PEG-based hydrogel structures. The nanoscale conformational change of enzyme, triggered by substrate recognition, translated into macroscopic motion of hydrogels.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599350 | PMC |
| http://dx.doi.org/10.1021/ja805634x | DOI Listing |
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