DC are a highly heterogeneous population that plays a critical role in host defense. We previously demonstrated that virus infection induces BM plasmacytoid DC (pDC) differentiation into CD11b(+) conventional DC (cDC) upon in vitro culture with Fms-like tyrosine kinase 3 ligand (Flt3L). Here we use immunoglobulin D-J rearrangements and pDC adoptive transfer to provide definitive proof supporting BM pDC conversion into CD11b(+) cDC during in vivo viral infection. We show that in vivo BM pDC conversion into CD11b(+) cDC relates to enhanced ability to prime virus-specific T cells. Furthermore, we demonstrate that in vivo pDC conversion does not rely on viral infection of BM pDC, but instead is mediated by type I IFN signaling. Finally, by exploiting recently identified pDC-specific Ab, we provide further characterizations of the BM pDC fraction that exhibits this broader developmental plasticity. Collectively, these data indicate that BM pDC actively contribute to the CD11b(+) cDC pool during in vivo viral infection and delineates molecular, functional, and phenotypic features of this novel developmental pathway.
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http://dx.doi.org/10.1002/eji.200838282 | DOI Listing |
Phys Chem Chem Phys
January 2025
School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
The hydrogenation of bicarbonate, a byproduct of CO captured in alkaline solutions, into formic acid (FA) using glycerol (GLY) as a hydrogen source offers a promising carbon-negative strategy for reducing CO emissions. While Pd-based catalysts are effective in this reaction, they often require high temperatures, leading to low FA yield due to strong hydrogen adsorption on Pd surfaces. In this work, metal-organic framework derived N-doped carbon encapsulated CoNi alloy nanoparticles (CoNi@NC) were prepared, acid-leached, and employed as a support to modulate the electronic structure of Pd-based catalysts.
View Article and Find Full Text PDFInorg Chem
January 2025
Institute for Energy Research, Institute of Carbon Neutrality Development, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Pd-based alloys are among the most attractive catalysts for direct alcohol fuel cells. However, their widespread use is limited by the high cost of Pd and their susceptibility to deactivation by surface-adsorbed reaction intermediates, particularly CO. In this study, we engineered an ultrathin 2D PdCr metallene to minimize Pd usage and doped it with phosphorus to enhance its CO tolerance.
View Article and Find Full Text PDFPhilos Trans A Math Phys Eng Sci
December 2024
Istituto di Fotonica e Nanotecnologie del CNR, Piazza Leonardo da Vinci 32, Milano 20133, Italy.
This work provides a mathematical derivation of a quasi-stationary (QS) model for multimode parametric down-conversion (PDC), which was presented in Gatti . (Gatti ., .
View Article and Find Full Text PDFChem Asian J
December 2024
Organic Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India.
We present a comprehensive account of our efforts directed towards the synthesis of sacubitril, a neprilysin inhibitor used in combination with valsartan and marketed as Entresto™. Our initial approach to the formal synthesis of sacubitril employed a chiral pool strategy, utilizing (S)-pyroglutamic acid as a key building block and Cu(I)-mediated Csp-Csp cross-coupling as a key transformation. Further investigations led to the development of chiral amine transfer (CAT) reagents-based stereoselective synthesis.
View Article and Find Full Text PDFChemSusChem
December 2024
Department of Energy, Environmental, and Chemical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St Louis, MO 63130, USA.
Chemical depolymerization of lignin is a non-selective process that often generates a wide distribution of product compounds, denoted herein as lignin breakdown products (LBPs). To address this limitation, we developed a hybrid lignin conversion process that employs a lignin-first catalytic approach on biomass and subsequent microbial upgrading. A Pd/C catalyst was used for reductive catalytic fractionation (RCF) of poplar biomass, and Rhodococcus opacus PD630 (R.
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