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Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration.
Mol Brain
January 2025
Research Centre for Idling Brain Science, University of Toyama, Toyama, 930-0194, Japan.
Cognitive processes such as action planning and decision-making require the integration of multiple sensory modalities in response to temporal cues, yet the underlying mechanism is not fully understood. Sleep has a crucial role for memory consolidation and promoting cognitive flexibility. Our aim is to identify the role of sleep in integrating different modalities to enhance cognitive flexibility and temporal task execution while identifying the specific brain regions that mediate this process.
View Article and Find Full Text PDFThe interplay between chromatin remodeling and DNA double-strand break repair: Implications for cancer biology and therapeutics.
DNA Repair (Amst)
January 2025
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:
Proper chromatin remodeling is crucial for many cellular physiological processes, including the repair of DNA double-strand break (DSB). While the mechanism of DSB repair is well understood, the connection between chromatin remodeling and DSB repair remains incompletely elucidated. In this review, we aim to highlight recent studies demonstrating the close relationship between chromatin remodeling and DSB repair.
View Article and Find Full Text PDFPRA-MutPred: Predicting the Effect of Point Mutations in Protein-RNA Complexes Using Structural Features.
J Chem Inf Model
January 2025
Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, 600036 Tamil Nadu, India.
Interactions between proteins and RNAs are essential for the proper functioning of cells, and mutations in these molecules may lead to diseases. These protein mutations alter the strength of interactions between the protein and RNA, generally described as binding affinity (Δ). Hence, the affinity change upon mutation (ΔΔ) is an important parameter for understanding the effect of mutations in protein-RNA complexes.
View Article and Find Full Text PDFSemi-Supervised Medical Image Segmentation Based on Frequency Domain Aware Stable Consistency Regularization.
J Imaging Inform Med
January 2025
Key Laboratory of Knowledge Engineering with Big Data (the Ministry of Education of China), Hefei University of Technology, Hefei, 230009, Anhui, China.
With the advancement of deep learning models nowadays, they have successfully applied in the semi-supervised medical image segmentation where there are few annotated medical images and a large number of unlabeled ones. A representative approach in this regard is the semi-supervised method based on consistency regularization, which improves model training by imposing consistency constraints (perturbations) on unlabeled data. However, the perturbations in this kind of methods are often artificially designed, which may introduce biases unfavorable to the model learning in the handling of medical image segmentation.
View Article and Find Full Text PDFTIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice.
Mucosal Immunol
January 2025
Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
Intestinal immune homeostasis relies on intestinal epithelial cells (IECs), which provide an efficient barrier, and warrant a state of tolerance between the microbiome and the mucosal immune system. Thus, proper epithelial microbial sensing and handling of microbes is key to preventing excessive immunity, such as seen in patients with inflammatory bowel disease (IBD). To date, the molecular underpinnings of these processes remain incompletely understood.
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