Inhibition of return (IOR) refers to slowed responses to targets presented at the same location as a preceding stimulus. We explored whether the IOR effect would increase with the number of cues preceding the target (a 'cue'). Subjects performed a Posner cueing task with 1-5 cue presentations prior to the target, to which they made either a manual localization (Experiment 1) or target discrimination response (Experiment 2). The cues could be the same as (Experiment 1), or differ in shape from (Experiment 2), the target. The results showed that regardless of cue-target congruency the IOR effect increased dramatically with the number of preceding cues. This increase was driven mostly by a linear slowing of reaction times to targets presented on the same side as the cue(s), suggesting that a process such as sensory adaptation and/or habituation may be a contributing mechanism to the IOR effect.
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http://dx.doi.org/10.1016/j.neulet.2008.10.063 | DOI Listing |
Biomacromolecules
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Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing, Jiangsu Province 210094, China.
Managing uncontrolled and noncompressible bleeding presents a major challenge in emergency trauma care. Methods to halt bleeding quickly and efficiently, without applying direct pressure on the wound, have become a key focus of research. Herein, a novel fructose-modified chitosan/gelatin composite sponge has been developed, exhibiting high elasticity, low rebound pressure, and excellent cell compatibility.
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Department of Psychological Science, University of California, Irvine, CA, USA.
Exposure therapy has been shown to be useful for the treatment of anxiety disorders. However, there are individual differences in the extent to which this intervention is effective in reducing symptoms, and a substantial number of patients may experience a return of fear (ROF). The factors associated with successful therapy outcomes are an important topic of investigation as these factors might influence the nature of the interventions as well as enhance our understanding of the process associated with the disorder and its treatment.
View Article and Find Full Text PDFJ Cogn
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University of Trier, Department of Cognitive Psychology, Germany.
Inhibition of return (IOR) refers to a location repetition cost typically observed when signaling the detection of or localizing sequentially presented stimuli repeating or changing their location. In discrimination tasks, however, IOR is often reduced or even absent; here, effects of binding and retrieval are thought to take place. Information is bound into an event file, which upon feature repetition causes retrieval, leading to partial repetition costs.
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Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane Minato-ku, Tokyo, 108-8641, Japan. Electronic address:
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View Article and Find Full Text PDFBiomed Pharmacother
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The Cole Eye Institute, The Cleveland Clinic, Cleveland, OH 44195, United States. Electronic address:
Several studies in rabbits demonstrated the efficacy and safety of topical losartan, an angiotensin II receptor blockers (ARB) that modulates the TGF-β intracellular signaling pathways by inhibiting the activation of Extracellular Signal-regulated Kinase (ERK), in preventing or treating stromal fibrosis after a range of injuries such as Descemetorhexis, alkali burns, incisions, and photorefractive keratectomy (PRK). Several case reports have shown that topical losartan treatment is also efficacious and safe in humans to prevent or treat stromal fibrosis after many different injuries or diseases. Topical losartan penetrates the full thickness of the cornea and, therefore, can treat both anterior and posterior stromal fibrosis.
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