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Desensitization of olipudase alfa-induced anaphylaxis in a child with chronic neurovisceral acid sphingomyelinase deficiency.
Mol Genet Metab Rep
September 2024
Department of Pediatrics, Buzzi Children's Hospital, Milan, Italy.
Unlabelled: Olipudase alfa is indicated for the non-central nervous system manifestations of Acid sphingomyelinase deficiency (ASMD). Anaphylaxis is a very rare and life-threatening adverse reaction described for this drug. Here, we report the case of a 2-year-old boy affected by chronic neurovisceral ASMD who experienced signs of hypersensitivity reactions to olipudase alfa since the administered dose of 1 mg/kg during dose escalation and a proper anaphylactic reaction during the second administration of the target therapeutic dose of 3 mg/kg.
View Article and Find Full Text PDFSuccessful rapid liposomal amphotericin B desensitization in pediatric case series.
Allergy Asthma Proc
May 2024
From the Department of Paediatric Allergy and Immunology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Liposomal amphotericin B (LAMB) is a crucial agent in the treatment of invasive fungal diseases caused by a wide variety of yeasts and molds. In the presence of an infection caused by a fungal agent resistant to alternative antifungal drugs, desensitization may be the only option to continue treatment. However, there is insufficient information and consensus with regard to amphotericin B desensitization protocols in the pediatric age group.
View Article and Find Full Text PDFPolyethylene glycol hypersensitivity, patient outcomes in a 7-year retrospective study.
Ann Allergy Asthma Immunol
July 2024
Department of Adult Allergy, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London, United Kingdom.
Background: Immediate IgE-mediated hypersensitivity reactions to polyethylene glycol (PEG) are rare. Our understanding of PEG hypersensitivity is limited.
Objective: To evaluate the clinical characteristics and investigation outcomes of the largest cohort of patients with PEG allergy reported.
Anaphylactic Shock After Cervical Conization Hemostasis With a Packing Soaked in Monsel's Solution.
Cureus
January 2024
Obstetrics and Gynecology, Centro Hospitalar Universitário de Santo António, Porto, PRT.
Anaphylactic shock is a life-threatening medical emergency, and its successful approach depends on early recognition and treatment. We present a case report of a 54-year-old female, with the American Society of Anesthesiology (ASA) Physical Status Classification III, admitted for cervical conization. She presented with known allergies to paracetamol, diclofenac, and nimesulide, and a history of nickel contact dermatitis, with no reports of complicated anesthesia.
View Article and Find Full Text PDFPotential Anaphylaxis to Systemic Phenylephrine: A Case Report.
Hosp Pharm
February 2024
Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
This case summarizes a 66 year old woman with a past medical history of asthma, breast cancer, anxiety, and chronic back pain with prior surgical insertion of spinal hardware, presenting for removal of spinal hardware at L5-S1 and spinal laminectomy and fusion at L4-L5. Her course was complicated by acute blood loss anemia and post-operative hypotension managed with a phenylephrine infusion, for which she experienced a possible anaphylactic reaction requiring upgrade to the intensive care unit. She was managed using intramuscular epinephrine, diphenhydramine, methylprednisolone, albuterol, famotidine, and oxygen.
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