In a previous manuscript [C. Andre, A. Berthelot, J.F. Robert, M. Thomassin, Y.C. Guillaume, J. Pharm. Bio. Med., in press], the Mg(2+) effect on the testosterone displacement equilibrium from its human serum albumin (HSA) binding site by DHEA was investigated using a thermodynamic approach. In this paper, a novel concept based on the competitive Langmuir distribution isotherms was proposed to calculate the association constant of the HSA-hormone binding and to confirm the Mg(2+) role on the testosterone displacement equilibrium from its HSA binding site by DHEA. Thus, both the HSA-hormone binding and the displacement equilibrium processes were reanalysed. The results obtained confirmed that:
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.talanta.2004.06.044 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Infanticide is driven by unfamiliarity with offspring location and associated with androgenic shifts in mimic poison frogs.
Horm Behav
November 2024
Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address:
Infanticide is widespread across the animal kingdom, but the physiological drivers of infanticide versus care or neglect are relatively unexplored. Here, we identified salient environmental and physiological antecedents of infanticide in the mimic poison frog (Ranitomeya imitator), a biparental amphibian. We explored potential environmental cues influencing infant-directed behavior by evaluating changes in the frequency of food provisioning and tadpole mortality after either cross-fostering tadpoles between family units or displacing tadpoles within the terraria of their parents.
View Article and Find Full Text PDFInfanticide is driven by unfamiliarity with offspring location and associated with androgenic shifts in mimic poison frogs.
bioRxiv
October 2024
Department of Biology, Stanford University, Stanford, CA 94305, USA.
Infanticide is widespread across the animal kingdom, but the physiological drivers of infanticide versus care or neglect are relatively unexplored. Here, we identified salient environmental and physiological antecedents of infanticide in the mimic poison frog (), a biparental amphibian in which female parents feed their tadpoles unfertilized eggs. Specifically, we explored potential environmental cues influencing infant-directed behavior by evaluating changes in the frequency of food provisioning and tadpole mortality after either cross-fostering tadpoles between family units or displacing tadpoles within the terraria of their parents.
View Article and Find Full Text PDFEvaluation of carotid artery elasticity and its influencing factors in non-obese PCOS patients using a technique for quantitative vascular elasticity measurement.
Front Endocrinol (Lausanne)
September 2024
Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- - The study aimed to assess the intima-media thickness (IMT) and elasticity of the carotid artery in non-obese women with polycystic ovary syndrome (PCOS) and identify factors influencing these measurements.
- - Researchers selected 60 non-obese PCOS patients and 60 healthy controls, examining various physical and hormonal metrics, as well as using ultrasound elastography to analyze arterial health.
- - Results showed that PCOS patients had a higher waist-to-hip ratio, elevated testosterone levels, and greater insulin resistance, highlighting significant differences in several health parameters compared to healthy controls.
Capacitation of ram spermatozoa promotes changes in energy metabolism and aquaporin 3 and is affected by individual testosterone variations.
Andrology
September 2024
Departament of Animal Reproduction, National Institute for Agricultural and Food Research and Technology (CSIC), Madrid, Spain.
Background: Recently, the metabolic pathways involved in energy production and the role of aquaglyceroporins in capacitation-associated events have been studied in humans and mice. However, little is known about these in ram spermatozoa.
Objective: The present study investigated bioenergetic and aquaglyceroporin 3 variations during in vitro capacitation of ram spermatozoa.
TLK1>Nek1 Axis Promotes Nuclear Retention and Activation of YAP with Implications for Castration-Resistant Prostate Cancer.
Cancers (Basel)
August 2024
Department of Biochemistry and Molecular Biology, The Feist Weiller Cancer Center, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.
Despite some advances in controlling the progression of prostate cancer (PCa) that is refractory to the use of ADT/ARSI, most patients eventually succumb to the disease, and there is a pressing need to understand the mechanisms that lead to the development of CRPC. A common mechanism is the ability to integrate AR signals from vanishing levels of testosterone, with the frequent participation of YAP as a co-activator, and pointing to the deregulation of the Hippo pathway as a major determinant. We have recently shown that YAP is post-transcriptionally activated via the TLK1>NEK1 axis by stabilizing phosphorylation at Y407.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!