Second-derivative synchronous fluorescence spectrometry was used to develop a simple, rapid and sensitive spectrofluorimetric method for the determination of binary mixtures of the nonsteroidal antiinflammatory drugs flufenamic (FFA), meclofenamic (MCFA) and mefenamic (MFA) acids in serum and pharmaceutical formulations. The method is based on the intrinsic fluorescence of these compounds in chloroform. A Deltalambda=105 nm was used for the resolution of FFA-MFA and MFA-MCFA mixtures, whereas the FFA-MCFA mixture was determined at Deltalambda=40 nm. Serum samples are treated with trichloroacetic acid to remove the proteins, and the analytes are extracted in chloroform prior to determination. Pharmaceutical preparations were analysed without prior separation steps.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0039-9140(98)00086-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chromatographic analysis and pK evaluation of active pharmaceutical ingredients in anti-metastatic breast cancer: Green vs. conventional RPLC.
J Pharm Biomed Anal
January 2025
Sabanci University Nanotechnology Research and Application Center (SUNUM), Istanbul 34956, Turkey.
This study aimed to determine the chromatographic retention and dissociation/protonation constant (pK) values of lapatinib and tamoxifen, key drugs used in metastatic breast cancer treatment, at 37°C using both conventional and green high-performance liquid chromatography (HPLC) methods. Qualitative analysis was conducted on an XTerra C18 column (250 ×4.6 mm I.
View Article and Find Full Text PDFFacile preparation of bifunctional monolayers through diazonium grafting and "click" postfunctionalization: A first step towards efficient aptasensing interfaces.
Bioelectrochemistry
January 2025
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, National University of Science and Technology Politehnica Bucharest, 1-7 Gheorghe Polizu St., 011061 Bucharest, Romania. Electronic address:
Herein, we present an efficient approach for developing electrochemical aptasensing interfaces, by "click" postfunctionalization of phenylethynyl-grafted glassy carbon substrates with mixed monolayers containing biorecognition elements and phosphorylcholine zwitterionic groups. Typically, controlling the composition of multicomponent surface layers by grafting from a mixture of aryldiazonium salts is challenging due to differences in their chemical reactivity. Our approach circumvents this issue by employing the electrochemical reduction of a single aryldiazonium salt containing a silyl-protected alkyne group followed by deprotection, to create phenylethynyl monolayers which can subsequently accommodate the concurrent immobilization of bioreceptors and zwitterionic groups through "click" postfunctionalization.
View Article and Find Full Text PDFMulti-organelle imaging with dye combinations: targeting the ER, mitochondria, and plasma membrane.
J Mater Chem B
January 2025
Department of Chemistry, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, India.
Multi-organelle imaging allows the visualization of multiple organelles within a single cell, allowing monitoring of the cellular processes in real-time using various fluorescent probes that target specific organelles. However, the limited availability of fluorophores and potential spectral overlap present challenges, and many optimized designs are still in nascency. In this work, we synthesized various sulfonamide-based organic fluorophores that emit in the blue, green, and red regions to target different sub-cellular organelles.
View Article and Find Full Text PDFDensity, Speed of Sound, Refractive Index, and the Derived Properties of Binary Mixtures of ,-Dimethylacetamide with 1-Butanol, 1-Pentanol, Furfural, or Furfuryl Alcohol at Different Temperatures.
J Chem Eng Data
January 2025
LATA2M, Laboratoire de Thermodynamique Appliquée et Modélisation Moléculaire, University of Tlemcen, Post Office Box 119, Tlemcen 13000, Algeria.
The density (ρ), speed of sound (), and refractive index ( ) of ,-dimethylacetamide (DMA) with 1-butanol, 1-pentanol, furfural (FFL), or furfuryl alcohol (FA) as a function of composition and at = 293.15 to 323.15 K with an interval of 10 K and atmospheric pressure were measured.
View Article and Find Full Text PDFDensity and Viscosity of CO-Loaded Aqueous 2-Amino-2-methyl-1-propanol (AMP) and Piperazine (PZ) Mixtures.
J Chem Eng Data
January 2025
Department of Chemical Engineering, Norwegian University of Science and Technology, Trondheim N-7491, Norway.
Densities and viscosities of aqueous 2-amino-2-methyl-1-propanol (AMP)/piperazine (PZ) solutions with and without CO are measured from 20 to 80 °C at ambient pressure. Redlich-Kister-based correlations are proposed for the excess molar volumes and viscosity deviation of the binary and ternary mixtures. Empirical correlations are developed to quantitatively describe the effect of CO on the density and viscosity of the aqueous AMP/PZ solutions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!