Phosphomolybdic acid is used as reagent for colorimetric determination of phenothiazine derivatives in various pharmaceutical products. The reagent oxidizes the derivative to a cationic free radical, with which it then forms a coloured salt. The method is simple and rapid. A preliminary extraction is necessary if certain reductants (sulphite or ascorbic acid) are present as stabilizers of the pharmaceuticals, as otherwise they reduce the reagent to phosphomolybdenum blue.
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http://dx.doi.org/10.1016/0039-9140(77)80169-0 | DOI Listing |
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