Neonatal herpes infection virus is rare but of poor prognosis. The only way to prevent it, is to practice a prophylactic caesarean section. In medically undeveloped countries, indication of caesarean section should be very prudent because of subsequent risks of uterine rupture. After a short recall about herpes illness, a precise and simple behaviour is proposed.
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Asymptomatic neonatal herpes simplex virus infection in mice leads to persistent CNS infection and long-term cognitive impairment.
PLoS Pathog
February 2025
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America.
Neonatal herpes simplex virus (nHSV) is a devastating infection impacting approximately 14,000 newborns globally each year. nHSV infection is associated with high neurologic morbidity and mortality, making early intervention critical. Clinical outcomes of symptomatic nHSV infections are well-studied, but little is known about the frequency of, or outcomes following, subclinical or asymptomatic nHSV.
View Article and Find Full Text PDFProteomic profiling of neonatal herpes simplex virus infection on dried blood spots.
Commun Med (Lond)
December 2024
Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Background: Neonatal herpes simplex virus (HSV) infection is life-threatening, with a mortality of up to 70-80% when disseminated, often due to vague symptoms and delayed treatment. Neonatal screening using dried blood spot (DBS) samples is among the most impactful preventative health measures ever implemented, but screening for HSV has not been investigated.
Methods: We investigated high throughput multiplexed proteomics on DBS samples collected on days 2-3 of life from a nationwide cohort of neonates with HSV infection (n = 53) and matched controls.
Estimated global and regional economic burden of genital herpes simplex virus infection among 15-49 year-olds in 2016.
BMC Glob Public Health
July 2024
Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
Background: Globally, herpes simplex virus (HSV)-2 and -1 infections contribute to a large disease burden, but their full economic consequences remain unclear. This study aims to estimate the global economic impact of genital HSV-2 and HSV-1 infection and its consequences for people with genital ulcer disease, neonatal herpes, and human immunodeficiency virus (HIV) infection attributable to HSV-2.
Methods: Using a societal perspective, the economic burden was calculated at the country level and presented by World Health Organization (WHO) regions and World-Bank income levels.
Israeli neonatal herpes simplex infection: Unique epidemiology and clinical profile.
J Med Virol
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Pediatric Infectious diseases Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
Article Synopsis
- A study conducted on Israeli neonatal herpes simplex virus (NHSV) infection collected data from 2015 to 2022, comparing clinical characteristics of NHSV patients with those suffering from neonatal enteroviral meningitis (NEM).
- The results showed an NHSV incidence of 5.9 per 100,000 live births, with notable demographics suggesting that horizontal transmission was linked to practices like ritual circumcision.
- NHSV patients presented unique symptoms such as a lower incidence of fever and irritability but showed a tendency for rashes and seizures, marking a distinct clinical profile compared to NEM, which can help guide treatment approaches for infected newborns.
Localized Neonatal Herpes on Eyes Without Ocular Involvement.
J Cutan Med Surg
September 2024
Chacha Nehru Bal Chikitsalaya, Delhi, India.
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