Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827790 PMC http://dx.doi.org/10.1155/2008/375617 DOI Listing Publication Analysis
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The association of 9p21-3 locus with coronary atherosclerosis: a systematic review and meta-analysis.
BMC Med Genet
June 2014
Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, USA.
Background: Studies suggest that the 9p21-3 locus may influence susceptibility to myocardial infarction. We performed a systematic review and meta-analysis to assess whether this locus is associated with severity of coronary atherosclerosis and adverse clinical outcomes in those with known coronary disease.
Methods: Multiple electronic databases were searched from inception through August 2012.
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