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Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy.
Cell Commun Signal
January 2025
Precision Medicine Laboratory for Chronic Non-Communicable Diseases of Shandong Province, Institute of Precision Medicine, Jining Medical University, Jining, 272067, China.
Initially, it was believed that glycolysis and DNA damage repair (DDR) were two distinct biological processes that independently regulate tumor progression. The former metabolic reprogramming rapidly generates energy and generous intermediate metabolites, supporting the synthetic metabolism and proliferation of tumor cells. While the DDR plays a pivotal role in preserving genomic stability, thus resisting cellular senescence and cell death under both physiological and radio-chemotherapy conditions.
View Article and Find Full Text PDFSimultaneous multimodal measures for aesthetic evaluation of furniture color and form.
Sci Rep
January 2025
Key Laboratory of Wood Material Science and Application (Beijing Forestry University), Ministry of Education, Beijing, 100083, China.
The tendency toward the aesthetic preference affects an individual's intention to purchase furniture. Color and form are two fundamental elements of furniture appearance. However, there is a significant lack of human-computer interaction research on the aesthetic evaluation of furniture with various colors and forms, necessitating a comprehensive study to provide theoretical and empirical support to furniture designers and businesses.
View Article and Find Full Text PDFSpatiotemporal network dynamics and structural correlates in the human cerebral cortex in vitro.
Prog Neurobiol
January 2025
Institute of Biomedical Investigations August Pi i Sunyer (IDIBAPS), Systems Neuroscience, 08036 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain. Electronic address:
Elucidating human cerebral cortex function is essential for understanding the physiological basis of both healthy and pathological brain states. We obtained extracellular local field potential recordings from cortical slices of neocortical tissue from refractory epilepsy patients. Multi-electrode recordings were combined with histological information, providing a two-dimensional spatiotemporal characterization of human cortical dynamics in control conditions and following modulation of the excitation/inhibition balance.
View Article and Find Full Text PDFRecent advance for enantiorecognition of chiral drugs sensing: Electrochemical, electrochemiluminescent and photoelectrochemical application.
Biosens Bioelectron
January 2025
School of Pharmacy, School of Clinical Medicine, Shandong Second Medical University, Weifang, 261053, China. Electronic address:
Chiral isomers show different behaviours and properties in physiological activities. It is of great significance to find productive approach to realize the recognition of enantiomers, which is a key issue in biochemical and pharmaceutical fields. Nowadays, chiral identification can be successfully achieved according to the discrepancies of special signals correlated with different enantiomers of multiple electrode structures.
View Article and Find Full Text PDFLoneliness is positively associated with populist radical right support.
Soc Sci Med
January 2025
University of Amsterdam, Amsterdam School of Communication Research, the Netherlands.
Objectives: The mental and physical health consequences of loneliness are well documented. However, loneliness's socio-political ramifications have been largely unexplored. We theorize that loneliness, due to its physiologically dysregulating impact on the nervous system, facilitates greater susceptibility towards populist radical right parties.
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