AI Article Synopsis
- The Apical Ectodermal Ridge (AER) plays a crucial role in limb development by managing growth and pattern formation along the proximo-distal axis.
- Recent research has provided insights into the cellular and molecular mechanisms that regulate the AER's development and functionality.
- This review aims to compile existing knowledge to create a comprehensive understanding of the AER, exploring its connections to dorso-ventral patterning and its overall significance in limb formation.
Article Abstract
The Apical Ectodermal Ridge (AER) is one of the main signaling centers during limb development. It controls outgrowth and patterning in the proximo-distal axis. In the last few years a considerable amount of new data regarding the cellular and molecular mechanisms underlying AER function and structure has been obtained. In this review, we describe and discuss current knowledge of the regulatory networks which control the induction, maturation and regression of the AER, as well as the link between dorso-ventral patterning and the formation and position of the AER. Our aim is to integrate both recent and old knowledge to produce a wider picture of the AER which enhances our understanding of this relevant structure.
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| http://dx.doi.org/10.1387/ijdb.072416mf | DOI Listing |
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