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This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674720 | PMC |
| http://dx.doi.org/10.1194/jlr.R800036-JLR200 | DOI Listing |
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