AI Article Synopsis
- Perillae fructus (perilla seed) is a traditional herb used for treating asthma, combined with acupuncture techniques at the ST36 point for enhanced therapeutic effects.
- A study on asthmatic mice showed that injecting this herbal extract significantly reduced lung inflammation, the number of inflammatory cells, and specific cytokine levels linked to allergic reactions.
- The findings indicate that Perillae fructus herbal acupuncture may help manage bronchial asthma by correcting immune system imbalances and reducing airway inflammation.
Article Abstract
Perillae fructus (perilla seed) is a traditional medicinal herb used to treat bronchial asthma in Oriental medical clinics. ST36 is one of the most widely used acupuncture points, particularly for immune system regulation. Injection of an herbal extract into an acupuncture point (herbal acupuncture) is a therapeutic technique combining both acupuncture and herbal treatment. Perillae fructus extract was injected subcutaneously (Perillae fructus herbal acupuncture; PF-HA) at acupoint ST36 of OVA-induced asthmatic mice. The lung weight, bronchoalveolar fluid (BALF) cell count, the number of CCR3+, CD11b+, CD4+ and CD3e+/CD69+ cells in the lung, and the level of IgE, IL-4, IL-5 and IL-13 in BALF and serum were then measured. RT-PCR was used to measure the mRNA expression of IL-4, IL-5, IL-13 and TNF-α in the lung. Lung sections were analyzed histologically. PF-HA significantly reduced lung weight, the number of inflammatory cells in the lung and BALF, the levels of IgE and Th2 cytokines in BALF and serum, mRNA expression of Th2 cytokines in the lung, and pathological changes in lung tissue. Our results suggest that PF-HA may have an anti-inflammatory and immune-regulatory effect on bronchial allergic asthma by restoring the Th1/Th2 imbalance in the immune system and suppressing eosinophilic inflammation in airways.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816376 | PMC |
| http://dx.doi.org/10.1093/ecam/nem118 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Perilla Seed Oil and Protein: Composition, Health Benefits, and Potential Applications in Functional Foods.
Molecules
November 2024
Heilongjiang Province Key Laboratory of Food Processing, Harbin 150086, China.
Perilla () seeds are emerging as a valuable resource for functional foods and medicines owing to their rich oil and protein content with diverse nutritional and health benefits. Perilla seed oil (PSO) possesses a high level of a-linolenic acid (ALA), a favorable ratio of unsaturated to saturated fatty acids, and other active ingredients such as tocopherols and phytosterols, which contribute to its antioxidant, anti-inflammatory, and cardiovascular protective effects. The balanced amino acid ratio and good functional properties of perilla seed protein make it suitable for a variety of food applications.
View Article and Find Full Text PDFInfluence of Secondary Metabolites According to Maturation of Perilla () on Respiratory Protective Effect in Fine Particulate Matter (PM2.5)-Induced Human Nasal Cell.
Int J Mol Sci
November 2024
Department of Southern Area Crop Science, National Institute of Crop Science, Rural Development Administration, Milyang 50424, Republic of Korea.
Article Synopsis
- * This study analyzed perilla seeds and flowers at various growth stages to determine the levels of beneficial metabolites, finding that flowers generally had higher functional components than seeds.
- * The research showed that perilla flowers, especially those harvested 20 days after flowering, provide significant respiratory protection by inhibiting harmful inflammatory markers and oxidative stress, suggesting their potential as a natural remedy.
Critical radicle length window governing loss of dehydration tolerance in germinated Perilla seeds: insights from physiological and transcriptomic analyses.
BMC Plant Biol
November 2024
School of Innovation and Intrepreneurship, Shanxi Agricultural University, Taigu, Shanxi, 030801, China.
Background: Perilla (Perilla frutescens L. Britt.) is an important oilseed and medicinal crop that frequently faces seasonal drought stress during seed germination, leading to a loss of dehydration tolerance (DT), which affects seed emergence and significantly reduces yield.
View Article and Find Full Text PDFImproved skeletal muscle mass and strength through Protamex-mediated hydrolysis of perilla seed cake: Elevated rosmarinic acid levels as a contributing factor.
Food Chem
January 2025
Department of Food Science and Technology, Seoul Women's University, Seoul 01797, Republic of Korea. Electronic address:
Perilla seed cake (PSC) is a byproduct of oil extraction from perilla seeds. It is rich in proteins and bioactive compounds. PSC was enzymatically hydrolyzed to form PSC hydrolysate (PSCH) to enhance the absorption of PSC, and their effects on muscle health in mice were compared.
View Article and Find Full Text PDFMultivariate Data Analysis Assisted Mining of Nutri-rich Genotypes from North Eastern Himalayan Germplasm Collection of Perilla (Perilla frutescens L.).
Plant Foods Hum Nutr
December 2024
Department of International Cooperation, Research Institute of Organic Agriculture FiBL, Frick, Switzerland.
Understanding the nutritional diversity in Perilla (Perilla frutescens L.) is essential for selecting and developing superior varieties with enhanced nutritional profiles in the North Eastern Himalayan (NEH) region of India. In this study, we assessed the nutritional composition of 45 diverse perilla germplasm collected from five NEH states using standard protocols and advanced analytical techniques.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!