STS are a heterogeneous group of malignant tumors that pose significant management challenges. The cornerstone of therapy for patients who have primary STS remains margin-negative resection. Adjuvant radiotherapy has been shown to reduce the risk of recurrence for extremity and trunk STS, although its role for retroperitoneal STS remains to be defined. Neoadjuvant radiotherapy has some theoretic advantages to postoperative radiation, but its exact role has yet to be determined. Chemotherapy is usually reserved for chemotherapy-sensitive histologic subtypes and for patients who have metastatic STS.
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