AI Article Synopsis
- Rfam is a database that contains RNA sequence families, using multiple sequence alignments and covariance models to help identify RNA sequences in genomes.
- The primary goal is to annotate new RNA members in known families by using advanced BLAST filters along with covariance models.
- The collection mainly features highly diverse RNA types like tRNA and rRNA for broad taxonomic annotations, while many others like snoRNAs and miRNAs focus on specific taxonomic ranges.
Article Abstract
Rfam is a collection of RNA sequence families, represented by multiple sequence alignments and covariance models (CMs). The primary aim of Rfam is to annotate new members of known RNA families on nucleotide sequences, particularly complete genomes, using sensitive BLAST filters in combination with CMs. A minority of families with a very broad taxonomic range (e.g. tRNA and rRNA) provide the majority of the sequence annotations, whilst the majority of Rfam families (e.g. snoRNAs and miRNAs) have a limited taxonomic range and provide a limited number of annotations. Recent improvements to the website, methodologies and data used by Rfam are discussed. Rfam is freely available on the Web at http://rfam.sanger.ac.uk/and http://rfam.janelia.org/.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686503 | PMC |
| http://dx.doi.org/10.1093/nar/gkn766 | DOI Listing |
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