Background And Purpose: The Micropos 4DRT system is being developed to provide accurate, precise, objective, and continuous target localization during radiotherapy. This study involves the first in vivo use of the system, aiming to evaluate the localization accuracy of this electromagnetic positioning technique compared with radiographic localization and to assess its real-time tracking ability.
Material And Methods: An active positioning marker was inserted in the prostatic urethra of 10 patients scheduled to receive radiotherapy for localized prostate cancer. A receiving sensor plate (antennae system) was placed at a known position in the treatment tabletop. Initial in vivo system calibrations were performed in three subjects. Ten additional patients were then enrolled in a study arm that compared radiographic transponder location to radiotransponder location simultaneously acquired by the Micropos 4DRT system. Frontal and side radiographs were taken with the radiopaque transponder located at three different positions within the prostatic urethra.
Results: The transponder insertions were all successful and without complications. Comparison of the transponder location as per the Micropos 4DRT system with the radiographic transponder localization showed an average (+/-SD) absolute and relative 3D difference of 2.7+/-1.2 and 1.7+/-1.0mm, respectively. Continuous transponder tracking capability was also demonstrated.
Conclusions: Electromagnetic positioning using the Micropos transponder system is feasible in vivo. Evaluation of this novel non-ionizing localization system, in this study using a transponder positioned in the prostatic urethra, indicates transponder localization accuracy to isocenter comparable with X-ray localization of a radiopaque marker.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.radonc.2008.08.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Performance-based habitat choice can drive rapid adaptive divergence and reproductive isolation.
Curr Biol
December 2024
Department of Molecular Biology and Biochemical Engineering, University Pablo de Olavide, Seville 41013, Spain. Electronic address:
Theory predicts that performance-based habitat choice-where individuals select environments based on their local performance-should be widespread in nature and significantly influence ecological and evolutionary processes, including local adaptation, population divergence, reproductive isolation, and speciation. However, experimental evidence supporting these predictions has been largely lacking. In this study, we addressed this by inducing performance-based habitat choice in wild tree sparrows (Passer montanus) through the manipulation of differential access to transponder-operated feeders in two adjacent woodland areas.
View Article and Find Full Text PDFBiocompatibility of intraperitoneally implanted TEMPO-oxidized cellulose nanofiber hydrogels for antigen delivery in Atlantic salmon (Salmo salar L.) vaccines.
Fish Shellfish Immunol
April 2024
Aquaculture Research Institute, University of Maine, Orono, ME, 04469, USA; Cooperative Extension, University of Maine, Orono, ME, 04469, USA.
Disease outbreaks are a major impediment to aquaculture production, and vaccines are integral for disease management. Vaccines can be expensive, vary in effectiveness, and come with adjuvant-induced adverse effects, causing fish welfare issues and negative economic impacts. Three-dimensional biopolymer hydrogels are an appealing new technology for vaccine delivery in aquaculture, with the potential for controlled release of multiple immunomodulators and antigens simultaneously, action as local depots, and tunable surface properties.
View Article and Find Full Text PDFONE SHOT - single shot radiotherapy for localized prostate cancer: 18-month results of a single arm, multicenter phase I/II trial.
Radiother Oncol
May 2024
Radiation Oncology, Geneva University Hospital, Geneva, Switzerland; Faculty of Medicine, Geneva University, Geneva, Switzerland.
Purpose: To assess in a prospective, multicenter, single-arm phase I/II study the early safety and efficacy profile of single fraction urethra-sparing stereotactic body radiotherapy (SBRT) for men with localized prostate cancer.
Material And Methods: Patients with low- and intermediate-risk localized prostate cancer without significant tumor in the transitional zone were recruited. A single-fraction of 19 Gy was delivered to the prostate, with 17 Gy dose-reduction to the urethra.
Revolutionizing localized prostate cancer treatment: Stereotactic radiotherapy "Moroccan experience".
Arch Ital Urol Androl
February 2024
Faculty of Medicine, University Hassan II, Casablanca.
Introduction: Prostate cancer is the most common urological cancer, and its incidence is increasing. Radical prostatectomy and radiotherapy are theprimary treatments for localized forms. Stereotactic Body RadioTherapy (SBRT), a new and innovative therapy, has been validated for some cancer localizations but not yet for localized prostate cancer.
View Article and Find Full Text PDFNesting Ecology of in Lobito, Angola.
Methods Protoc
December 2023
Department of Biology, University of Aveiro, 3800-193 Aveiro, Portugal.
The scarcity on the Atlantic coast of the African sea turtle population and its dynamics data is well known. This article discusses the nesting ecology methods and analysis of a nascent Angolan project aimed at preserving the nesting female population of the Olive Ridley turtle () on the coast of Lobito. This study examines the nesting ecology of this species from 2020 to 2023.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!