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[Survivin in cancerology : molecular aspects and therapeutic applications]. | LitMetric

[Survivin in cancerology : molecular aspects and therapeutic applications].

Med Sci (Paris)

Inserm, Université de Nantes, UMR 892, Département de recherche en cancérologie 9 quai Moncousu, 44093 Nantes, France.

Published: October 2008

AI Article Synopsis

Article Abstract

Discovered 10 years ago, survivin has a dual role in the smooth progress of mitosis and in apoptosis resistance. Survivin plays an important physiological role in development, but is absent in differentiated adult tissues. In contrast, aberrant survivin expression is found in most human cancers because of the activation of various signalling pathways. A complex survivin network appears to intersect multiple pathways in cell biology, related to several molecular partners and fine subcellular localizations. Based on its pro-oncogenic properties, basic and translational studies have shown a growing interest in survivin that has led to consider survivin as a prognostic marker and a promising target for anti-tumoral therapies.

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Source
http://dx.doi.org/10.1051/medsci/20082410821DOI Listing

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