Purpose: Exudative age-related macular degeneration was classified into two types. Type 1 had choroidal neovascularization (CNV) below the retinal pigment epithelium (RPE) and type 1+2 had CNV extended into subretinal space. The morphological changes following photodynamic therapy were investigated for the two types.
Patients And Methods: One hundred and five eyes of 104 patients(mean age; 70.2 +/- 8.5 (SD) years-old) were classified by clinical findings with stereoscopic fundus observation, fluorescein angiography, and optical coherent tomography. The eyes with no exudative changes after successful treatment were divided into two types: sub-pigment epithelial dry type and sub-sensory retinal dry type. In the former, the lesions remained below the RPE and in the latter, fibrous scars persisted in the subretinal space.
Results: Exudation resolved in 73% of type 1 and in 67% of type 1+2 at 6 months after the initial treatment. Among eyes followed for more than one year, in 77% of type 1 and in 89% of type 1+2 the lesions became dry in a mean follow-up time of 23.9 -/+ 8.4 months with mean treatment times of 2.0 and 2.2, respectively. Type 1 improved to sub-pigment epithelial dry type, and type 1+2 to sub-sensory retinal dry type (p = 1.06 x 10(-10), chi-square test). Visual acuity of the former was better than the latter.
Conclusions: We considered that exudation was resolved with CNV remaining beneath the RPE in type 1, and fibrous scar tissue was favorably formed in type 1+2.
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