Cross-regulation between herpesviruses and the TNF superfamily members.

Nat Rev Immunol

Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.

Published: November 2008

Herpesviruses have evolved numerous strategies to subvert host immune responses so they can coexist with their host species. These viruses 'co-opt' host genes for entry into host cells and then express immunomodulatory genes, including mimics of members of the tumour-necrosis factor (TNF) superfamily, that initiate and alter host-cell signalling pathways. TNF superfamily members have crucial roles in controlling herpesvirus infection by mediating the direct killing of infected cells and by enhancing immune responses. Despite these strong immune responses, herpesviruses persist in a latent form, which suggests a dynamic relationship between the host immune system and the virus that results in a balance between host survival and viral control.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665163PMC
http://dx.doi.org/10.1038/nri2434DOI Listing

Publication Analysis

Top Keywords

tnf superfamily
12
immune responses
12
superfamily members
8
host immune
8
host
6
cross-regulation herpesviruses
4
herpesviruses tnf
4
members herpesviruses
4
herpesviruses evolved
4
evolved numerous
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!