The discovery of equipotent PPARalpha/gamma dual activators.

Bioorg Med Chem Lett

Department of Medicinal Chemistry, Laboratoire GlaxoSmithKline, Centre de Recherches, 25-27 avenue du Québec, 91951 Les Ulis, France.

Published: December 2008

We report the design and synthesis of equipotent PPARalpha/gamma dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.

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http://dx.doi.org/10.1016/j.bmcl.2008.09.094DOI Listing

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