AI Article Synopsis
- John Auer identified needle-shaped inclusion bodies, known as Auer rods, in leukemia cells in 1906.
- Auer rods are found in myeloid neoplasms, particularly in acute myeloid leukemias and myelodysplastic syndromes, but not in normal or reactive conditions.
- The article reviews Auer's historical findings, explores ongoing debates regarding Auer rods, and critiques their role in defining refractory anemia with excess of blasts-2 (RAEB-2) in the WHO classification of myelodysplastic syndromes.
Article Abstract
John Auer first described needle or rod-shaped intracytoplasmic inclusion bodies in leukemia cells in 1906. Auer rods can be seen in myeloid neoplasms ranging from acute myeloid leukemias (AML) to myelodysplasia, but not in normal or non-neoplastic reactive states. This article briefly describes John Auer's experience and discusses debates on Auer rods, and criticizes their place in the definition of refractory anemia with excess of blasts-2 (RAEB-2) in the WHO classification of the myelodysplastic syndromes (MDS).
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| http://dx.doi.org/10.1016/j.leukres.2008.09.014 | DOI Listing |
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