Objective: Bladder spasms are a common cause of pain after surgical procedures that call for postoperative catheter drainage. Several therapeutic methods have been used to lessen these spasms but none have received widespread success.
Patients And Methods: Twenty-six children were included in a prospective randomized trial to evaluate the safety and efficacy of daily intravesical instillation of ropivacaine as prophylactic treatment for bladder spasms following ureteroneocystostomy.
Results: Although six patients experienced mild transient pain during instillation, there was no systemic toxicity attributable to the ropivacaine. The average number of spasms per day fell by half in the instillation group (p<0.01).
Conclusion: Intravesical instillation of ropivacaine is a feasible alternative prophylactic treatment for postoperative bladder spasms.
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http://dx.doi.org/10.1016/j.jpurol.2006.11.003 | DOI Listing |
Clin Cancer Res
December 2024
United States Food and Drug Administration, Silver Spring, Maryland, United States.
On December 16, 2022, the FDA approved the adenoviral vector-based gene therapy nadofaragene firadenovec-vncg (brand name Adstiladrin) for the treatment of adult patients with high-risk bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS). The product represents the first approved adenoviral vector-based gene therapy and the first approved gene therapy for bladder cancer. Determination of efficacy was based on results from Study rAd-IFN-CS-003 (Study CS-003), a single-arm trial in 98 evaluable patients with BCG-unresponsive NMIBC with CIS who received intravesical instillations of the gene therapy product (75 mL of nadofaragene firadenovec at 3 × 1011 viral particles per mL) once every 3 months.
View Article and Find Full Text PDFOpen Med (Wars)
November 2024
Department of Urology, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, No. 1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang, 313000, China.
Background: Bladder cancer, a significant health concern worldwide, often necessitates diverse surgical interventions and postoperative treatments. Understanding the complications arising from these procedures is vital for enhancing patient outcomes and quality of life.
Methods: This study encompassed 80 bladder cancer patients, evaluating their demographic characteristics, systemic conditions, cancer stages, tumor diameter, surgical procedures, and postoperative treatments.
Diagnostics (Basel)
September 2024
Department of Radiology, Mayo Clinic, Phoenix, AZ 85054, USA.
Bronchial-subarachnoid fistulas are rare occurrences, which are not well defined in the literature. This uncommon clinical phenomenon may result in symptomatic pneumorrhachis and presents unique clinical challenges. This report details a case of a 53-year-old female whose treatment for recurrent chondrosarcoma of the thoracic spine included multiple surgeries and radiotherapy.
View Article and Find Full Text PDFNurse Educ Today
January 2025
School of Nursing, Faculty of Science, Medicine & Health, University of Wollongong, Australia, Australian Centre for Integration of Oral Health (ACIOH), Ingham Institute for Applied Medical Research, Building 41: Room 118, University of Wollongong, NSW, 2522, Australia. Electronic address:
Background: Nurses play a critical role in supporting patients in self-managing their indwelling urinary catheters and preventing avoidable hospital presentations. This study aimed to explore the effectiveness of a co-designed educational approach developed to enhance nurses' ability to provide optimal care for patients with catheters.
Aim: The primary aim of this study was to enhance nurses' knowledge and skills in urinary catheterisation, care, and management.
Cureus
September 2024
Neurosurgery, Taipei Veterans General Hospital, Taipei, TWN.
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