A human immunodeficiency virus type 1 (HIV-1)-infected elite controller (defined as an untreated HIV-1-infected person with a plasma HIV-1 RNA level <50 copies/mL for at least 12 months) who experienced a viremic episode after superinfection regained natural viremic control, although the viral loads in the patient's 2 partners, infected with the same viral strain, were continuously approximately 30-fold higher. Thus, host mechanisms seem to be able to repeatedly control HIV-1 replication, halting disease progression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1086/592978 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates.
Mol Ther
January 2025
Department of Biological Engineering, Massachusetts Institute of Technology; Cambridge, MA, USA, 02139; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, USA, 02139; Department of Chemical Engineering, Massachusetts Institute of Technology; Cambridge, MA, USA, 02139; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University; Cambridge, MA, USA, 02139; Howard Hughes Medical Institute; Chevy Chase, MD, USA, 20815; Department of Materials Science of Engineering; Massachusetts Institute of Technology; Cambridge, MA, USA, 02139. Electronic address:
mRNA delivered using lipid nanoparticles (LNPs) has become an important subunit vaccine modality, but mechanisms of action for mRNA vaccines remain incompletely understood. Here, we synthesized a metal chelator-lipid conjugate enabling positron emission tomography (PET) tracer labeling of LNP/mRNA vaccines for quantitative visualization of vaccine trafficking in live mice and non-human primates (NHPs). Following i.
View Article and Find Full Text PDFBariatric surgery and HIV: Joint venture between family, primary care, and HIV physicians.
J Family Med Prim Care
December 2024
Department of HIV and Blood Borne Viruses, Milton Keynes University Hospital, NHS Foundation Trust, Milton Keynes, UK.
We report a case of a 49-year-old female with a history of HIV infection for 12 years. The patient had excellent compliance with antiretroviral medications, raltegravir 400 mg twice daily and truvada once daily for HIV. Over the years, she maintained an undetectable viral load with a CD4+ count >200 cells/μL.
View Article and Find Full Text PDFMultifocal Head and Neck Tumor in a Patient With HIV: A Rare Case.
Cureus
December 2024
Internal Medicine, National University of Malaysia, Kuala Lumpur, MYS.
Epstein-Barr virus-associated smooth muscle tumors (EBV-SMTs) are a rare type of tumor occurring exclusively in immunocompromised patients in the setting of HIV/AIDS, post-organ transplant, and congenital immunodeficiency. These tumors require demonstration of EBV DNA on histopathologic studies in order to establish a diagnosis. The overall prognosis is good.
View Article and Find Full Text PDFAssociation Between County-Level Social Vulnerability and CDC-funded HIV Testing Program Outcomes in the United States, 2020-2022.
J Acquir Immune Defic Syndr
January 2025
Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Background: Community-level social vulnerabilities may affect HIV outcomes. This analysis assessed the association between county-level social vulnerability and CDC-funded HIV testing program outcomes.
Setting: HIV testing data from 60 state and local health departments and 119 community-based organizations were submitted to CDC during 2020-2022.
Under-nutrition and its associated factors among adult second-line antiretroviral treatment users in Northern Ethiopia.
BMC Public Health
January 2025
Department of Public Health, Woldia University, Woldia, Ethiopia.
Background: Despite advancements in Human Immunodeficiency Virus (HIV) treatment and care, undernutrition remains a significant concern, accelerating disease progression and risk of Acquired Immune Deficiency Syndrome (AIDS)-related deaths. The nutritional status of second-line antiretroviral treatment (SLART) users in Ethiopia has not been thoroughly investigated. So, this study aimed to assess the nutritional status of HIV/AIDS patients who were on SLART and its associated factors in Northern Ethiopia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!