AI Article Synopsis
- The study aimed to see if allopurinol, a medication that inhibits xanthine oxidase, could improve nitric oxide activity in the brain of individuals with type 2 diabetes, which is linked to higher stroke risk.
- Results showed that after a two-week treatment with allopurinol, participants had improved blood flow responses in the internal carotid artery compared to those on a placebo.
- Overall, the findings suggest that allopurinol may enhance nitric oxide availability in the brain, potentially reducing stroke risk in these patients.
Article Abstract
Objective: Type 2 diabetes increases risk of stroke, perhaps because of impaired cerebrovascular basal nitric oxide (NO) activity. We investigated whether this activity is improved by a 2-week course of the xanthine oxidase inhibitor allopurinol.
Research Design And Methods: We performed a randomized, double-blind, placebo-controlled crossover study. We measured the response to infusion of NG-monomethyl-L-arginine (l-NMMA) in males with type 2 diabetes before and after allopurinol or placebo. The primary end point was the change in internal carotid artery flow following L-NMMA infusion, expressed as the area under the flow-per-time curve.
Results: We enrolled 14 participants. Allopurinol improved responses to L-NMMA when compared with responses associated with placebo (P = 0.032; median reduction in internal carotid artery flow following L-NMMA of 3,144 ml [95% CI 375-7,143]).
Conclusions: Xanthine oxidase inhibition with allopurinol appears to improve cerebral NO bioavailability, as evidenced by a greater response to infusion of L-NMMA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606848 | PMC |
| http://dx.doi.org/10.2337/dc08-1179 | DOI Listing |
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