An effective procedure for preoperative chemoradiotherapy is suggested to intensify treatment of patients with extensive, local and/or regional, metastases of breast cancer. It uses medication followed by accelerated radiotherapy which offers the combined advantages of "concentrated" and "conventional" irradiation. High local and systemic effect is produced right at the outset thus making use of high-cost "first-line" cytostatics unnecessary and avoiding delay of surgical intervention.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review).
Mol Clin Oncol
March 2025
Department of Orthopaedics, Mianyang Central Hospital, Mianyang, Sichuan 621000, P.R. China.
Ultra-high dose rate radiotherapy defined as FLASH radiotherapy is a potential technology to improve local tumor therapeutic gain ratio. It relies on linear accelerator capable of delivering large doses in a single microsecond pulse (>40 Gy/sec). This therapy would lead to sparing of normal tissue which has been termed the FLASH effect.
View Article and Find Full Text PDFDeep learning-based quick MLC sequencing for MRI-guided online adaptive radiotherapy: a feasibility study for pancreatic cancer patients.
Phys Med Biol
January 2025
Department of Radiation Oncology, Division of Medical Physics and Engineering , UT Southwestern Medical Center, 2280 Inwood Road, Dallas, Texas, 75390-9096, UNITED STATES.
One bottleneck of MRI-guided Online Adaptive Radiotherapy (MRoART) is the time-consuming daily online replanning process. The current leaf sequencing method takes up to 10 minutes, with potential dosimetric degradation and small segment openings that increase delivery time. This work aims to replace this process with a fast deep learning-based method to provide deliverable MLC sequences almost instantaneously, potentially accelerating and enhancing online adaption.
View Article and Find Full Text PDFLongitudinal assessment of diffusion-weighted imaging during magnetic resonance-guided radiotherapy in head and neck cancer.
Radiat Oncol
January 2025
German Cancer Consortium (DKTK), partner site Tübingen, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Background: For radiotherapy of head and neck cancer (HNC) magnetic resonance imaging (MRI) plays a pivotal role due to its high soft tissue contrast. Moreover, it offers the potential to acquire functional information through diffusion weighted imaging (DWI) with the potential to personalize treatment. The aim of this study was to acquire repetitive DWI during the course of online adaptive radiotherapy on an 1.
View Article and Find Full Text PDFA preliminary study of linear accelerator-based spatially fractionated radiotherapy.
Front Oncol
January 2025
Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Purpose: This study aimed to provide quantitative information for implementing Lattice radiotherapy (LRT) using a medical linear accelerator equipped with the Millennium 120 multi-leaf collimator (MLC). The research systematically evaluated the impact of varying vertex diameters and separations on dose distribution, peak-to-valley dose ratio (PVDR), and normal tissue dose.
Methods: A cylindrical Virtual Water™ phantom was used to create LRT treatments using the Eclipse version 16.
Spatial accuracy of dose delivery significantly impacts the planning target volume margin in linear accelerator-based intracranial stereotactic radiosurgery.
Sci Rep
January 2025
Radiation Safety and Quality Assurance division, National Cancer Center Hospital East, Chiba, 277-8577, Japan.
The impact of three-dimensional (3D) dose delivery accuracy of C-arm linacs on the planning target volume (PTV) margin was evaluated for non-coplanar intracranial stereotactic radiosurgery (SRS). A multi-institutional 3D starshot test using beams from seven directions was conducted at 22 clinics using Varian and Elekta linacs with X-ray CT-based polymer gel dosimeters. Variability in dose delivery accuracy was observed, with the distance between the imaging isocenter and each beam exceeding 1 mm at one institution for Varian and nine institutions for Elekta.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!