Age-related changes in female skin microrelief (82 nonsmoking and smoking women at the age from 17 to 80 years) were analyzed by the use of VISIOSCAN VS 98. Measurements were taken on inner side of left forearm at the distance of 2 cm away from the bend of elbow. It was demonstrated that such parameters as relievo (V) and roughness (Ser) increased respectively by a factor of 1,23 and 1,50 times in average in group of smoking women of 17 to 28 years old as compared with nonsmoking women of age mate. The statistically valid differences were well documented using the representative samples. On the basis of the results of these studies we can conclude that smoking has a systemic effect on the whole-body skin.

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