Journal of the American Chemical Society

1520-5126130462008Nov19Journal of the American Chemical SocietyJ Am Chem SocPreparation of fluorescent magnetic nanodiamonds and cellular imaging.154761548115476-8110.1021/ja804253yMagnetic nanodiamonds were prepared via solid-state microwave arcing of a nanodiamond-ferrocene mixed powder in a focused microwave oven. High-resolution transmission electron microscope (HRTEM) images show that a magnetic nanodiamond is composed of iron nanoparticles encapsulated by graphene layers on the surface of nanodiamonds. Fluorescence property was introduced onto magnetic nanodiamonds by chemical modification of magnetic nanodiamonds via surface grafting of poly(acrylic acids) and fluorescein o-methacrylate. Fluorescent magnetic nanodiamonds are water soluble with a solubility of approximately 2.1 g/L. Cellular-imaging experiments show that fluorescent magnetic nanodiamonds could be ingested by HeLa cells readily in the absence of agonist (i.e., folate) moieties on the surface of nanodiamonds.ChangIn PinIPDepartment of Chemistry, National Tsing Hua University, Hsinchu, Taiwan.HwangKuo ChuKCChiangChi-ShiunCSengJournal ArticleResearch Support, Non-U.S. Gov't20081022