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Cognitive variation reflects amyloid, tau, and neurodegenerative biomarkers in Alzheimer's disease.
Geroscience
January 2025
Psychology, School of Social Sciences, Nanyang Technological University, 48 Nanyang Avenue S639818, Singapore, Singapore.
In Alzheimer's disease (AD), the accumulation of neuropathological markers such as amyloid-β plaques, neurofibrillary tangles, and cortical neurodegeneration occurs over many years before overt manifestation of cognitive impairment. There is thus a need for neuropsychological markers that are indicative of pathological changes in the early stages of the disease. Intra-individual cognitive variability (IICV), defined as the variation of an individual's performance across cognitive domains, is a promising neuropsychological marker measuring heterogeneous changes in cognition that may reflect these early pathological changes.
View Article and Find Full Text PDFThe value of privacy for people with dementia.
Front Psychiatry
January 2025
Ethics in Medicine, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.
Introduction: The concept of privacy marks an astonishing gap in the discussion about care for people with dementia (PwD). In general, questions of privacy play an important role and attract much attention in the ethics of nursing care. Yet, when it comes to dementia care, there is hardly any systematic ethical debate on the topic at all.
View Article and Find Full Text PDFA multi-person reflection on using public and patient involvement and engagement to develop dementia research.
Res Involv Engagem
January 2025
, Suffolk, UK.
Involving people living with dementia in the development of research through PPIE is the gold standard for ethical research. Established PPIE groups have been set up throughout the UK to provide people with dementia opportunities to have their voice heard. However, accessing these groups as a doctoral researcher can be difficult, and little guidance is given on how to make the process successful.
View Article and Find Full Text PDFCharacteristics of TSPO expression in marmoset EAE.
J Neuroinflammation
January 2025
Viral Immunology Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Building 10, Room 5C103, 10 Center Drive, Bethesda, MD, 20892-1400, USA.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) and is a leading non-traumatic cause of disability in young adults. The 18 kDa Translocator Protein (TSPO) is a mitochondrial protein and positron emission tomography (PET)-imaging target that is highly expressed in MS brain lesions. It is used as an inflammatory biomarker and has been proposed as a therapeutic target.
View Article and Find Full Text PDFStudying Alzheimer's disease through an integrative serum metabolomic and lipoproteomic approach.
J Transl Med
January 2025
Center for Memory Disturbances, Laboratory of Clinical Neurochemistry, Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, 06129, Italy.
Background: Alzheimer's disease (AD) is the most frequent neurodegenerative disorder worldwide. The great variability in disease evolution and the incomplete understanding of the molecular mechanisms underlying AD make it difficult to predict when a patient will convert from prodromal stage to dementia. We hypothesize that metabolic alterations present at the level of the brain could be reflected at a systemic level in blood serum of patients, and that these alterations could be used as prognostic biomarkers.
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