Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Follow-up assessment of the microvascular function in patients with long COVID.
Microvasc Res
January 2025
Department of Cardiac Diagnostics, Medical University of Gdansk, Poland. Electronic address:
Long COVID is a complex pathophysiological condition. However, accumulating data suggests that COVID-19 is a systemic microvascular endothelial dysfunction with different clinical manifestations. In this study, a microvascular function was assessed in long COVID patients (n = 33) and healthy controls (n = 30) using flow-mediated skin fluorescence technique (FMSF), based on measurements of nicotinamide adenine dinucleotide fluorescence intensity during brachial artery occlusion (ischemic response, IR) and immediately after occlusion (hyperemic response, HR).
View Article and Find Full Text PDFAcute Sympathetic Blockade Improves Insulin-Mediated Microvascular Blood Flow in the Forearm of Adult Human Subjects With Obesity.
J Am Heart Assoc
August 2024
Division of Clinical Pharmacology, Department of Medicine Vanderbilt University Medical Center Nashville TN.
Article Synopsis
- Obesity is linked to insulin resistance, affecting both glucose uptake and the body's blood vessel response to insulin, which is crucial for delivering glucose to tissues.
- A study tested the role of sympathetic activation in impaired insulin-triggered blood vessel dilation in obese adults using a controlled experiment with insulin and drugs to block sympathetic responses.
- Results showed that blocking sympathetic activation significantly improved blood flow and microvascular function when insulin was administered, indicating that sympathetic activity may hinder insulin's vascular effects in obesity.
Effect of acute intravenous beta-blocker administration on myocardial blood flow during same-day hybrid CCTA/PET imaging.
Int J Cardiovasc Imaging
October 2024
Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland.
This study aimed to evaluate the impact of acute intravenous beta-blocker administration on myocardial blood flow (MBF) during same-day hybrid coronary computed tomography angiography (CCTA) and 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI). Previous research on the discontinuation of oral beta-blockers before MPI has shown mixed results, with no studies yet exploring the acute intravenous administration in the context of same-day hybrid imaging. This retrospective study included patients with suspected chronic coronary syndromes undergoing same-day hybrid CCTA/13N-ammonia PET MPI.
View Article and Find Full Text PDFEffects on cerebral blood flow after single doses of the β agonist, clenbuterol, in healthy volunteers and patients with mild cognitive impairment or Parkinson's disease.
Br J Clin Pharmacol
October 2024
CuraSen Therapeutics, San Carlos, California, USA.
Aims: Cerebral hypometabolism occurs years prior to a diagnosis of neurodegenerative diseases and coincides with reduced cerebral perfusion and declining noradrenergic transmission from the locus coeruleus. In pre-clinical models, β-adrenoceptor (β-AR) agonists increase cerebrocortical glucose metabolism, and may have therapeutic potential for neurodegenerative diseases. This study investigated the safety and effects on regional cerebral blood flow (rCBF) of the oral, brain-penetrant β-AR agonist, clenbuterol, in healthy volunteers (HV) and patients with mild cognitive impairment (MCI) or Parkinson's disease (PD).
View Article and Find Full Text PDFFunctional autoantibodies against G protein-coupled receptors in hepatic and pulmonary hypertensions in human schistosomiasis.
Front Immunol
July 2024
Berlin Cures GmbH, Berlin, Germany.
Introduction: Schistosomiasis (SM) is a parasitic disease caused by . SM causes chronic inflammation induced by parasitic eggs, with collagen/fibrosis deposition in the granuloma process in the liver, spleen, central nervous system, kidneys, and lungs. Pulmonary arterial hypertension (PAH) is a clinical manifestation characterized by high pressure in the pulmonary circulation and right ventricular overload.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!