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Rikkunshito improves anorexia through ghrelin- and orexin-dependent activation of the brain hypothalamus and mesolimbic dopaminergic pathway in rats.
Neurogastroenterol Motil
November 2024
Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Kawagoe City, Saitama, Japan.
Background: Rikkunshito (RKT), a traditional Japanese medicine, can relieve epigastric discomfort and anorexia in patients with functional dyspepsia. RKT enhances the orexigenic hormone, ghrelin. Ghrelin regulates food motivation by stimulating the appetite control center in the hypothalamus and the brain mesolimbic dopaminergic pathway (MDPW).
View Article and Find Full Text PDFCurrent status of Complementary and Alternative Medicine Interventions in the Management of Pancreatic Cancer - An Overview.
Curr Treat Options Oncol
December 2023
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 5, 92-215, Lodz, Poland.
Article Synopsis
- - Pancreatic cancer is highly lethal, with most patients diagnosed at advanced stages, resulting in poor outcomes and prompting interest in complementary and alternative medicine (CAM) options.
- - CAM encompasses various non-Western medical practices and treatments, including natural products that may alleviate symptoms and improve quality of life for patients suffering from pancreatic cancer despite having mixed evidence regarding their effectiveness.
- - Key CAM therapies, often rooted in traditional Chinese or Japanese medicine, include substances like Curcuma longa, Panax ginseng, and several injections which are being explored as potential adjuncts to conventional treatments for pancreatic cancer.
A study related to the treatment of gastric cancer with Xiang-Sha-Liu-Jun-Zi-Tang based on network analysis.
Heliyon
September 2023
Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, PR China.
Purpose: Xiang-Sha-Liu-Jun-Zi-Tang(XSLJZT) is a common formula for the treatment of Gastric Cancer(GC) and is widely used in clinical practice, however, there is a lack of investigation into its mechanism.
Methods: We collected and organized drug and disease targets, constructed the "XSLJZT-Active Ingredient-Target" visualization network, and performed GO and KEGG functional enrichment analysis of crossover genes, followed by molecular docking of active ingredients and core targets. The best docked monomers were combined with weighted gene co-expression network analysis(WGCNA) and macroscopically analyzed by GO and KEGG enrichment techniques.
Treatment of dyspeptic symptoms with YamatoGast. A non-interventional study of a registered traditional herbal Rikkunshito extract product from Japanese Kampo Medicine in routine practice in Germany.
Z Gastroenterol
June 2024
G. Pohl-Boskamp GmbH und Co KG, Hohenlockstedt, Germany.
Introduction: Dyspeptic symptoms belong to the most frequent reasons to seek medical advice and are a burden both for the individual affected and the healthcare system. In Japan, the traditional herbal Kampo prescription has proven benefit for this indication.
Methods: In a prospective, multicentre, non-interventional study (NIS), the effectiveness, safety, and tolerability of a two-week treatment with the registered extract product was assessed in German patients with an acute episode of dyspeptic symptoms of functional origin under real-world conditions.
Antiemetic Effect of Rikkunshito, a Japanese Kampo Herbal Medicine, on Cisplatin-induced Nausea and Vomiting: A Nationwide Database Study in Japan.
Intern Med
April 2024
Department of Clinical Epidemiology and Health Economics, School of Public Health, the University of Tokyo, Japan.
Objective The effect of Rikkunshito, a Japanese herbal Kampo medicine, on chemotherapy-induced nausea and vomiting (CINV) has been evaluated in several small prospective studies, with mixed results. We retrospectively evaluated the antiemetic effects of Rikkunshito in patients undergoing cisplatin-based chemotherapy using a large-scale database in Japan. Methods The Diagnosis Procedure Combination inpatient database from July 2010 to March 2019 was used to compare adult patients with malignant tumors who had received Rikkunshito on or before the day of cisplatin administration (Rikkunshito group) and those who had not (control group).
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